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signal peptide peptidase like 2B

Summary

Gene Symbol

SPPL2B

Organism

Homo sapiens (human)

External Links

NCBI Gene

56928

PubChem

56928

Alliance of Genome Resources

HGNC:30627

Annotation

Keyword

Alternative splicing
Cell membrane
Endosome
Glycoprotein
Golgi apparatus
Lysosome
Protease
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TCT7	Intramembrane protease 4 Presenilin homologous protein 4 Presenilin-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
membrane protein ectodomain proteolysis	IDA	16829951 17965014
regulation of tumor necrosis factor-mediated signaling pathway	TAS
membrane protein intracellular domain proteolysis	IDA	16829951 19114711
membrane protein intracellular domain proteolysis	IMP	16829952 22194595
membrane protein proteolysis	IDA	2313285

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

regulation of immune response

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IEA
nucleoplasm	IDA
lysosomal membrane	IDA	15998642
lysosomal membrane	IBA
centrosome	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

microtubule organizing center [inference]

centrosome

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of endoplasmic reticulum membrane

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	17965014 2313285 32814053
aspartic endopeptidase activity, intramembrane cleaving	TAS
aspartic endopeptidase activity, intramembrane cleaving	IDA	2313285
aspartic endopeptidase activity, intramembrane cleaving	IMP	16873890 19114711 22194595
aspartic endopeptidase activity, intramembrane cleaving	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

signal peptide peptidase-like

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
aspartic endopeptidase activity, intramembrane cleaving
hydrolase activity
membrane protein proteolysis

Displaying **all 3** entries
InterPro
PA domain
Peptidase A22B, signal peptide peptidase
Presenilin/signal peptide peptidase

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	56928	Xenbase:XB-GENE-958186
Caenorhabditis elegans	66552	WB:WBGene00007979
Mus musculus	73218	Xenbase:XB-GENE-958186	MOUSE02850
Caenorhabditis elegans	84888	WB:WBGene00007979
Caenorhabditis elegans	162540	WB:WBGene00007979
Caenorhabditis elegans	237958	WB:WBGene00007979
Danio rerio	325540		DANRE29637
Rattus norvegicus	362828	Xenbase:XB-GENE-958186	RATNO38076
Bos taurus	504285		BOVIN32983
Pan troglodytes	750100		PANTR16717