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arginyl-tRNA synthetase 2, mitochondrial

Summary

Gene Symbol

RARS2

Organism

Homo sapiens (human)

External Links

NCBI Gene

57038

KEGG Gene ID

PubChem

57038

Alliance of Genome Resources

HGNC:21406

Annotation

Keyword

ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Disease variant
Membrane
Mitochondrion
Neurodegeneration
Pontocerebellar hypoplasia
Protein biosynthesis
Proteomics identification
Reference proteome
Transit peptide

Proteins

Displaying **all 4** entries
UniProt	Protein Name
H0UI22	Arginyl-tRNA synthetase
A0A8I5KWC6	Arginyl-tRNA synthetase
A0A8I5KPZ0	Arginyl-tRNA synthetase
Q5T160	Arginyl-tRNA synthetase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
tRNA metabolic process	IEA
tRNA aminoacylation for protein translation	TAS
tRNA aminoacylation for protein translation	IEA
arginyl-tRNA aminoacylation	IEA
gene expression	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

mitochondrial translation

gene expression

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

mitochondrial translation

gene expression

protein metabolic process [inference]

translation [inference]

mitochondrial translation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

arginyl-tRNA aminoacylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

arginyl-tRNA aminoacylation

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

arginyl-tRNA aminoacylation

protein metabolic process [inference]

translation [inference]

mitochondrial translation

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
cytoplasm	IEA
mitochondrion	IBA
mitochondrion	HTP
mitochondrial matrix	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

mitochondrial membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleotide binding	IEA
RNA binding	HDA
aminoacyl-tRNA ligase activity	IEA
arginine-tRNA ligase activity	TAS
arginine-tRNA ligase activity	IMP

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-oxygen bonds [inference]

aminoacyl-tRNA ligase activity

arginine-tRNA ligase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

aminoacyl-tRNA ligase activity

arginine-tRNA ligase activity

binding [inference]

nucleic acid binding [inference]

RNA binding

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060275	pontocerebellar hypoplasia type 6	Alliance of Genome Resources

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Last updated: April 6, 2026

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