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kinetochore scaffold 1

Summary

Gene Symbol

KNL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

57082

PubChem

57082

Alliance of Genome Resources

HGNC:24054

JoGo

KNL1

TogoVar

KNL1

Annotation

Keyword

3D-structure
Alternative splicing
Centromere
Chromosomal rearrangement
Chromosome
Chromosome partition
Coiled coil
Cytoplasm
Disease variant
Intellectual disability
Kinetochore
Mitosis
Nucleus
Phosphoprotein
Primary microcephaly
Proteomics identification
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8NG31	ALL1-fused gene from chromosome 15q14 protein Bub-linking kinetochore protein Cancer susceptibility candidate gene 5 protein Cancer/testis antigen 29 Kinetochore scaffold 1 Kinetochore-null protein 1 Protein CASC5 Protein D40/AF15q14

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
protein localization to kinetochore	IDA	22331848
protein localization to kinetochore	IBA
cell division	IEA
regulation of mitotic cell cycle spindle assembly checkpoint	IMP	19893618
positive regulation of meiosis I spindle assembly checkpoint	ISS

GO Hierarchy

biological process

cellular process [inference]

cell cycle process [inference]

chromosome segregation [inference]

nuclear chromosome segregation [inference]

sister chromatid segregation [inference]

mitotic sister chromatid segregation

attachment of spindle microtubules to kinetochore

mitotic cell cycle process [inference]

mitotic sister chromatid segregation

cellular process involved in reproduction in multicellular organism [inference]

acrosome assembly

cell division

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, centromeric region [inference]

protein localization to kinetochore

protein localization to condensed chromosome [inference]

protein localization to kinetochore

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

secretory granule organization [inference]

acrosome assembly

chromosome organization [inference]

sister chromatid segregation [inference]

mitotic sister chromatid segregation

organelle assembly [inference]

acrosome assembly

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

acrosome assembly

organelle assembly [inference]

acrosome assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

acrosome assembly

cellular process involved in reproduction in multicellular organism [inference]

acrosome assembly

homologous chromosome orientation in meiotic metaphase I

developmental process [inference]

developmental process involved in reproduction [inference]

acrosome assembly

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

acrosome assembly

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, centromeric region [inference]

protein localization to kinetochore

protein localization to condensed chromosome [inference]

protein localization to kinetochore

organelle localization [inference]

chromosome localization [inference]

homologous chromosome orientation in meiotic metaphase I

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, centromeric region [inference]

protein localization to kinetochore

protein localization to condensed chromosome [inference]

protein localization to kinetochore

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of reproductive process [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of chromosome organization [inference]

regulation of sister chromatid segregation [inference]

regulation of mitotic sister chromatid segregation [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of metaphase/anaphase transition of meiotic cell cycle [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of nuclear division [inference]

regulation of mitotic nuclear division [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of meiotic nuclear division [inference]

regulation of meiosis I [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic nuclear division [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of cell cycle process [inference]

regulation of mitotic nuclear division [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of meiotic nuclear division [inference]

regulation of meiosis I [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of chromosome segregation [inference]

regulation of sister chromatid segregation [inference]

regulation of mitotic sister chromatid segregation [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of metaphase/anaphase transition of meiotic cell cycle [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of chromosome separation [inference]

regulation of mitotic sister chromatid separation [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of meiotic chromosome separation [inference]

regulation of metaphase/anaphase transition of meiotic cell cycle [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell cycle process [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of cell cycle phase transition [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of meiotic cell cycle phase transition [inference]

regulation of metaphase/anaphase transition of meiotic cell cycle [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of metaphase/anaphase transition of meiotic cell cycle [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of meiotic cell cycle [inference]

regulation of meiotic nuclear division [inference]

regulation of meiosis I [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of reproductive process [inference]

regulation of meiotic cell cycle [inference]

regulation of meiotic nuclear division [inference]

regulation of meiosis I [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of meiotic cell cycle phase transition [inference]

regulation of metaphase/anaphase transition of meiotic cell cycle [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of meiotic chromosome separation [inference]

regulation of metaphase/anaphase transition of meiotic cell cycle [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of reproductive process [inference]

positive regulation of meiosis I spindle assembly checkpoint

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
kinetochore	NAS	21633384 23418356
kinetochore	IDA	15371340 19893618
outer kinetochore	IDA	24530301
acrosomal vesicle	IDA	15579588
nucleus	IDA	10980622

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular non-membrane-bounded organelle [inference]

kinetochore

supramolecular complex [inference]

kinetochore

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15231748 15502821 17981135 19141287 19389623 20220147 20231380 20360068 20819937 22000412 22331848 22660415 24530301 26496610 27881301 28514442 30100357 33961781
microtubule binding	IDA	30100357

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0070291	primary autosomal recessive microcephaly 4	Alliance of Genome Resources
DOID:0070296	primary autosomal recessive microcephaly	Alliance of Genome Resources
DOID:1115	sarcoma	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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