GlyCosmos Portal

Annotation

Keyword

3D-structure
Alternative splicing
Centromere
Chromosomal rearrangement
Chromosome
Chromosome partition
Coiled coil
Disease variant
Intellectual disability
Kinetochore
Mitosis
Nucleus
Phosphoprotein
Primary microcephaly
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8NG31	ALL1-fused gene from chromosome 15q14 protein Bub-linking kinetochore protein Cancer susceptibility candidate gene 5 protein Cancer/testis antigen 29 Kinetochore-null protein 1 Protein CASC5 Protein D40/AF15q14

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
mitotic sister chromatid segregation	IMP	19893618
acrosome assembly	NAS	15579588
attachment of spindle microtubules to kinetochore	IDA	17981135
attachment of spindle microtubules to kinetochore	IBA
homologous chromosome orientation in meiotic metaphase I	ISS

GO Hierarchy

biological process

cellular process [inference]

cell cycle process [inference]

chromosome segregation [inference]

nuclear chromosome segregation [inference]

sister chromatid segregation [inference]

mitotic sister chromatid segregation

attachment of spindle microtubules to kinetochore

mitotic cell cycle process [inference]

mitotic sister chromatid segregation

cellular process involved in reproduction in multicellular organism [inference]

acrosome assembly

cell division

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, centromeric region [inference]

protein localization to kinetochore

protein localization to condensed chromosome [inference]

protein localization to kinetochore

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

secretory granule organization [inference]

acrosome assembly

chromosome organization [inference]

sister chromatid segregation [inference]

mitotic sister chromatid segregation

organelle assembly [inference]

acrosome assembly

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

acrosome assembly

organelle assembly [inference]

acrosome assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

acrosome assembly

cellular process involved in reproduction in multicellular organism [inference]

acrosome assembly

homologous chromosome orientation in meiotic metaphase I

developmental process [inference]

developmental process involved in reproduction [inference]

acrosome assembly

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

acrosome assembly

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, centromeric region [inference]

protein localization to kinetochore

protein localization to condensed chromosome [inference]

protein localization to kinetochore

organelle localization [inference]

chromosome localization [inference]

homologous chromosome orientation in meiotic metaphase I

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, centromeric region [inference]

protein localization to kinetochore

protein localization to condensed chromosome [inference]

protein localization to kinetochore

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of reproductive process [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of chromosome organization [inference]

regulation of sister chromatid segregation [inference]

regulation of mitotic sister chromatid segregation [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of metaphase/anaphase transition of meiotic cell cycle [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of nuclear division [inference]

regulation of mitotic nuclear division [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of meiotic nuclear division [inference]

regulation of meiosis I [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic nuclear division [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of cell cycle process [inference]

regulation of mitotic nuclear division [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of meiotic nuclear division [inference]

regulation of meiosis I [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of chromosome segregation [inference]

regulation of sister chromatid segregation [inference]

regulation of mitotic sister chromatid segregation [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of metaphase/anaphase transition of meiotic cell cycle [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of chromosome separation [inference]

regulation of mitotic sister chromatid separation [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of meiotic chromosome separation [inference]

regulation of metaphase/anaphase transition of meiotic cell cycle [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell cycle process [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of cell cycle phase transition [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of meiotic cell cycle phase transition [inference]

regulation of metaphase/anaphase transition of meiotic cell cycle [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint

regulation of metaphase/anaphase transition of meiotic cell cycle [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of meiotic cell cycle [inference]

regulation of meiotic nuclear division [inference]

regulation of meiosis I [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of reproductive process [inference]

regulation of meiotic cell cycle [inference]

regulation of meiotic nuclear division [inference]

regulation of meiosis I [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of meiotic cell cycle phase transition [inference]

regulation of metaphase/anaphase transition of meiotic cell cycle [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

regulation of meiotic chromosome separation [inference]

regulation of metaphase/anaphase transition of meiotic cell cycle [inference]

regulation of meiosis I spindle assembly checkpoint [inference]

positive regulation of meiosis I spindle assembly checkpoint

positive regulation of reproductive process [inference]

positive regulation of meiosis I spindle assembly checkpoint

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA
cytosol	TAS
nuclear body	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular non-membrane-bounded organelle [inference]

kinetochore

supramolecular complex [inference]

kinetochore

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15231748 15502821 17981135 19141287 19389623 20220147 20231380 20360068 20819937 22000412 22331848 22660415 24530301 26496610 27881301 28514442 30100357 33961781
microtubule binding	IDA	30100357

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Kinetochore scaffold 1

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cell division
protein localization to kinetochore

Displaying **all 2** entries
InterPro
Kinetochore scaffold 1
Knl1, C-terminal RWD domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0070291	primary autosomal recessive microcephaly 4	Alliance of Genome Resources
DOID:0070296	primary autosomal recessive microcephaly	Alliance of Genome Resources
DOID:1115	sarcoma	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 40 in total

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Species	Gene ID	Orthologous MAtrix
Aotus nancymaae	105724079	AOTNA30311
Taeniopygia guttata	105759275	TAEGU26153
Propithecus coquereli	105814300	PROCO01652
Equus asinus asinus	106830881	EQUAS17987
Rhinopithecus bieti	108523405	RHIBE37857
Vulpes vulpes	112919807	VULVU12224
Corvus moneduloides	116445818	CORMO23909
Rhinolophus ferrumequinum	117023048	RHIFE31204
Balaenoptera musculus	118891204	BALMU29886
Panthera leo	122222184	PANLE19082

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

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Acknowledgements