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proteasome 26S subunit, non-ATPase 3

Summary

Gene Symbol

PSMD3

Organism

Homo sapiens (human)

External Links

NCBI Gene

5709

PubChem

5709

Alliance of Genome Resources

HGNC:9560

Annotation

Keyword

3D-structure
Alternative splicing
Isopeptide bond
Phosphoprotein
Proteasome
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
O43242	26S proteasome regulatory subunit RPN3 26S proteasome regulatory subunit S3 Proteasome subunit p58

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
ubiquitin-dependent protein catabolic process	IBA
regulation of protein catabolic process	IEA
proteasome-mediated ubiquitin-dependent protein catabolic process	NAS	19489727

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of protein catabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
proteasome complex	NAS	29636472
proteasome complex	IDA	17323924
extracellular region	TAS
nucleus	HDA	21630459
nucleoplasm	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

proteasome complex

catalytic complex [inference]

peptidase complex [inference]

endopeptidase complex [inference]

proteasome complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

ficolin-1-rich granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15147878 16990800 25036637 25416956 25814554 25910212 26030138 31515488 32296183 32814053 33961781 35271311
enzyme regulator activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular function regulator activity [inference]

enzyme regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

26S proteasome non-ATPase regulatory subunit 3

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
26S proteasome regulatory subunit, C-terminal
Proteasome component (PCI) domain
Winged helix DNA-binding domain superfamily

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5709	Xenbase:XB-GENE-958537
Mus musculus	22123	Xenbase:XB-GENE-958537	MOUSE03481
Rattus norvegicus	287670		RATNO02464
Danio rerio	393544		DANRE15282
Pan troglodytes	454640		PANTR14050
Canis lupus familiaris	491018		CANLF18780
Bos taurus	504937		BOVIN13226
Macaca mulatta	698712		MACMU13668
Monodelphis domestica	100015745		MONDO13751
Equus caballus	100147612		HORSE02977