GlyCosmos Portal

Annotation

Keyword

Alternative splicing
Cell membrane
Cytoplasm
Disease variant
Glycoprotein
Hydrolase
Isopeptide bond
Lipid degradation
Lipid droplet
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96AD5	Adipose triglyceride lipase Calcium-independent phospholipase A2-zeta Desnutrin Pigment epithelium-derived factor receptor TTS2.2 Transport-secretion protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
diacylglycerol biosynthetic process	ISS
triglyceride catabolic process	IBA IEA ISS
intracellular triglyceride homeostasis	IMP	28578400
lipid droplet disassembly	IMP	16239926
lipid storage	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

hormone metabolic process [inference]

retinol metabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol acyl-chain remodeling

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol acyl-chain remodeling

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol acyl-chain remodeling

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol acyl-chain remodeling

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol acyl-chain remodeling

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol acyl-chain remodeling

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

olefinic compound metabolic process [inference]

retinol metabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol acyl-chain remodeling

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol acyl-chain remodeling

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

lipid droplet organization [inference]

organelle fusion [inference]

lipid droplet fusion

organelle disassembly [inference]

lipid droplet disassembly

cellular component disassembly [inference]

organelle disassembly [inference]

lipid droplet disassembly

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular triglyceride homeostasis

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular triglyceride homeostasis

lipid homeostasis

acylglycerol homeostasis [inference]

triglyceride homeostasis [inference]

intracellular triglyceride homeostasis

localization [inference]

maintenance of location [inference]

lipid storage

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of cellular catabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of cellular catabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of lipid catabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of cellular catabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of cellular catabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of lipid catabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of localization [inference]

regulation of lipid storage [inference]

negative regulation of lipid storage [inference]

negative regulation of sequestering of triglyceride

regulation of sequestering of triglyceride [inference]

negative regulation of sequestering of triglyceride

regulation of lipid localization [inference]

negative regulation of lipid localization [inference]

negative regulation of lipid storage [inference]

negative regulation of sequestering of triglyceride

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

negative regulation of biological process [inference]

negative regulation of lipid localization [inference]

negative regulation of lipid storage [inference]

negative regulation of sequestering of triglyceride

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of cellular catabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of cellular catabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

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GO Term	Evidence Code	PMID
endoplasmic reticulum lumen
cytosol	IEA
cytoplasm	IBA ISS
lipid droplet	IBA IDA	16239926 21498505 28578400 34903883
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

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GO Term	Evidence Code	PMID
mono-olein transacylation activity	IDA	15364929
phospholipase A2 activity	IDA	15364929 17032652
acylglycerol O-acyltransferase activity	IDA TAS	17603008
triglyceride lipase activity	EXP IBA IDA IMP ISS TAS	15364929 15550674 16150821 16239926 17603008 34903883
diolein transacylation activity	IDA	15364929

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity [inference]

acylglycerol O-acyltransferase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase A2 activity

triglyceride lipase activity

lipoprotein lipase activity

carboxylic ester hydrolase activity [inference]

phospholipase A2 activity

triglyceride lipase activity

lipoprotein lipase activity

retinyl-palmitate esterase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000177666

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K16816

Name

patatin-like phospholipase domain-containing protein 2 [EC:3.1.1.3]

References

Rhea

RHEA:15801

H₂O + a 1,2-diacyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + a 1-acyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.4

PMID

RHEA:36231

H₂O + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + 1-O-alkyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.4

PMID

9442064

RHEA:12044

H₂O + a triacylglycerol

H⁺ + a diacylglycerol + a fatty acid

Enzyme

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **213** in total

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DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	DisGeNET
DOID:0040085	bacterial sepsis	DisGeNET
DOID:0050476	Barth syndrome	DisGeNET
DOID:0050535	exudative vitreoretinopathy	DisGeNET
DOID:0050572	cone-rod dystrophy	DisGeNET
DOID:0050585	congenital generalized lipodystrophy	DisGeNET
DOID:0050700	cardiomyopathy	DisGeNET
DOID:0050729	Chanarin-Dorfman syndrome	DisGeNET Alliance of Genome Resources
DOID:0050742	nicotine dependence	DisGeNET
DOID:0050782	Zollinger-Ellison syndrome	DisGeNET

The Human Phenotype Ontology

Displaying entries **21 - 30** of 64 in total

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HPO ID	HPO Term
HP:0001677	Coronary artery atherosclerosis
HP:0001681	Angina pectoris
HP:0001733	Pancreatitis
HP:0001744	Splenomegaly
HP:0001922	Vacuolated lymphocytes
HP:0001962	Palpitations
HP:0002094	Dyspnea
HP:0002155	Hypertriglyceridemia
HP:0002240	Hepatomegaly
HP:0002355	Difficulty walking

Displaying **all 3** entries
Disease ID	Disease Name
ORPHA:565612	triglyceride deposit cardiomyovasculopathy
OMIM:610717	neutral lipid storage myopathy
ORPHA:98908	neutral lipid storage myopathy

PubChem Disease

GHR Health Conditions

Neutral lipid storage disease with myopathy

MedGen Diseases

Neutral lipid storage myopathy

OMIM Phenotypes

NEUTRAL LIPID STORAGE DISEASE WITH MYOPATHY; NLSDM

KEGG Diseases

Neutral lipid storage disease with myopathy

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006638
Gene Name: patatin-like phospholipase domain containing 2

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175910	WB:WBGene00015484
Drosophila melanogaster	32436	FB:FBgn0030607
Drosophila melanogaster	39611	FB:FBgn0036449
Danio rerio	101887155	ZFIN:ZDB-GENE-120913-3	DANRE28091
Astyanax mexicanus	103029861		ASTMX02193
Electrophorus electricus	113588195		ELEEL40974
Esox lucius	105018061		ESOLU55487
Salmo trutta	115197722		SALTR11881
Gadus morhua	115551187		GADMO60603
Poecilia reticulata	103466503		POERE29095

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements