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peptidoglycan recognition protein 4

Summary

Gene Symbol

PGLYRP4

Organism

Homo sapiens (human)

External Links

NCBI Gene

57115

PubChem

57115

Alliance of Genome Resources

HGNC:30015

Annotation

Keyword

3D-structure
Alternative splicing
Antibiotic
Disulfide bond
Glycoprotein
Innate immunity
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96LB8	Peptidoglycan recognition protein I-beta Peptidoglycan recognition protein intermediate beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
immune response	IBA
peptidoglycan catabolic process	IEA
detection of bacterium	IDA	11461926
killing of cells of another organism	IDA	16354652
defense response to bacterium	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response

humoral immune response [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

cellular process [inference]

cell killing [inference]

killing of cells of another organism

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

detection of bacterium

defense response to bacterium

defense response to Gram-positive bacterium

defense response to other organism [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

defense response to bacterium

defense response to Gram-positive bacterium

innate immune response

detection of other organism [inference]

detection of bacterium

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

defense response to bacterium

defense response to Gram-positive bacterium

innate immune response

immune response

humoral immune response [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

detection of bacterium

defense response to bacterium

defense response to Gram-positive bacterium

defense response to other organism [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

defense response to bacterium

defense response to Gram-positive bacterium

innate immune response

detection of other organism [inference]

detection of bacterium

detection of external biotic stimulus [inference]

detection of other organism [inference]

detection of bacterium

response to biotic stimulus [inference]

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of other organism [inference]

detection of bacterium

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

detection of bacterium

defense response to bacterium

defense response to Gram-positive bacterium

defense response to other organism [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

defense response to bacterium

defense response to Gram-positive bacterium

innate immune response

detection of other organism [inference]

detection of bacterium

detection of external biotic stimulus [inference]

detection of other organism [inference]

detection of bacterium

detection of stimulus [inference]

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of other organism [inference]

detection of bacterium

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
membrane	NAS	11461926
protein-containing complex	IDA	16354652

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
zinc ion binding	IEA
N-acetylmuramoyl-L-alanine amidase activity	IEA
peptidoglycan immune receptor activity	IDA	11461926
peptidoglycan binding	IDA	11461926 16354652 17502600
protein heterodimerization activity	IPI	16354652

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

N-acetylmuramoyl-L-alanine amidase activity

peptidoglycan muralytic activity [inference]

N-acetylmuramoyl-L-alanine amidase activity

binding [inference]

protein binding [inference]

protein dimerization activity [inference]

protein heterodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

peptidoglycan binding

molecular transducer activity [inference]

signaling receptor activity [inference]

pattern recognition receptor activity [inference]

peptidoglycan immune receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Peptidoglycan recognition protein

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 2** entries
Gene Ontology
N-acetylmuramoyl-L-alanine amidase activity
zinc ion binding

Displaying **all 4** entries
InterPro
N-acetylmuramoyl-L-alanine amidase domain
N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily
Peptidoglycan recognition protein family domain, metazoa/bacteria
Peptidoglycan recognition protein

Ortholog

Displaying entries **1 - 10** of 45 in total

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Species	Gene ID	Alliance of Genome Resources
Danio rerio	8993	ZFIN:ZDB-GENE-050419-71
Drosophila melanogaster	32099	FB:FBgn0030310
Danio rerio	35859	ZFIN:ZDB-GENE-050419-71
Danio rerio	35862	ZFIN:ZDB-GENE-050419-71
Drosophila melanogaster	39064	FB:FBgn0035977
Danio rerio	39870	ZFIN:ZDB-GENE-050419-71
Danio rerio	41379	ZFIN:ZDB-GENE-050419-71
Danio rerio	57115	ZFIN:ZDB-GENE-050419-71
Drosophila melanogaster	57757	FB:FBgn0030310
Drosophila melanogaster	114770	FB:FBgn0030310