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solute carrier family 12, member 5

Summary

Gene Symbol

Slc12a5

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

57138

PubChem

57138

Alliance of Genome Resources

MGI:1862037

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cell projection
Chloride
Direct protein sequencing
Disulfide bond
Glycoprotein
Metal-binding
Phosphoprotein
Potassium transport
Proteomics identification
Reference proteome
Symport
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A076FRG6	Electroneutral potassium-chloride cotransporter 2 K-Cl cotransporter 2 Neuronal K-Cl cotransporter
A0A076FR46	Electroneutral potassium-chloride cotransporter 2 K-Cl cotransporter 2 Neuronal K-Cl cotransporter
A0A076FSX1	Electroneutral potassium-chloride cotransporter 2 K-Cl cotransporter 2 Neuronal K-Cl cotransporter
Q91V14	Electroneutral potassium-chloride cotransporter 2 K-Cl cotransporter 2 Neuronal K-Cl cotransporter

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 33 in total

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GO Term	Evidence Code	PMID
ion transport	ISS
monoatomic ion transport	ISS
ion transport	ISO
monoatomic ion transport	ISO
potassium ion transport	ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cellular localization [inference]

localization within membrane [inference]

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

ammonium transmembrane transport

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

learning or memory [inference]

learning

thermosensory behavior

multicellular organism growth

developmental process [inference]

anatomical structure development [inference]

dendritic spine development

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

potassium ion homeostasis

monoatomic anion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

chloride ion homeostasis

intracellular chloride ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

inorganic ion homeostasis [inference]

chloride ion homeostasis

intracellular chloride ion homeostasis

potassium ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to osmotic stress [inference]

hypotonic response

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hypotonic response

response to temperature stimulus [inference]

thermosensory behavior

response to chemical [inference]

response to xenobiotic stimulus

localization [inference]

protein-containing complex localization [inference]

receptor localization to synapse [inference]

postsynaptic neurotransmitter receptor diffusion trapping

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transport [inference]

chloride transport

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

ammonium transmembrane transport

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

nitrogen compound transport [inference]

ammonium transmembrane transport

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

cellular localization [inference]

localization within membrane [inference]

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of biological quality [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

postsynaptic neurotransmitter receptor diffusion trapping

Displaying entries **11 - 15** of 16 in total

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GO Term	Evidence Code	PMID
perikaryon	ISO
perikaryon	IEA
cell periphery	ISO
cell periphery	IDA	25716834
glutamatergic synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

dendrite membrane

synaptic membrane [inference]

postsynaptic specialization membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

leading edge membrane [inference]

neuron projection membrane [inference]

dendrite membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

cell body [inference]

neuronal cell body

cell periphery

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
ammonium transmembrane transporter activity	ISO
ammonium transmembrane transporter activity	IEA
chloride transmembrane transporter activity	ISO
potassium:chloride symporter activity	ISS
potassium:chloride symporter activity	ISO