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ATPase phospholipid transporting 8B2

Summary

Gene Symbol

ATP8B2

Organism

Homo sapiens (human)

External Links

NCBI Gene

57198

PubChem

57198

Alliance of Genome Resources

HGNC:13534

JoGo

ATP8B2

TogoVar

ATP8B2

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Endoplasmic reticulum
Lipid transport
Magnesium
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Translocase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P98198	ATPase class I type 8B member 2 P4-ATPase flippase complex alpha subunit ATP8B2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
Golgi organization	IBA
ion transmembrane transport	TAS
monoatomic ion transmembrane transport	TAS
phospholipid translocation	IBA

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

Golgi organization

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

organic substance transport [inference]

lipid transport [inference]

phospholipid transport [inference]

phospholipid translocation

lipid translocation [inference]

phospholipid translocation

organophosphate ester transport [inference]

phospholipid transport [inference]

phospholipid translocation

biological regulation [inference]

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

Displaying entries **1 - 5** of 9 in total

1

2

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GO Term	Evidence Code	PMID
nucleolus	IDA
endoplasmic reticulum membrane	IEA
Golgi apparatus	IDA	20947505
trans-Golgi network	IBA
cytosol	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

transporter complex [inference]

phospholipid-translocating ATPase complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	IEA
protein binding	IPI	20947505 20961850
ATP binding	IEA
ATP hydrolysis activity	IEA
phosphatidylcholine floppase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity [inference]

phosphatidylcholine transporter activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylcholine flippase activity

intramembrane lipid transporter activity [inference]

ATPase-coupled intramembrane lipid transporter activity

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylcholine flippase activity

floppase activity [inference]

phosphatidylcholine floppase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled intramembrane lipid transporter activity

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylcholine flippase activity

floppase activity [inference]

phosphatidylcholine floppase activity

Gene Ontology information from NCBI Gene and UniProt.

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Last updated: April 6, 2026

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