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adhesion G protein-coupled receptor G6

Summary

Gene Symbol

ADGRG6

Organism

Homo sapiens (human)

External Links

NCBI Gene

57211

PubChem

57211

Alliance of Genome Resources

HGNC:13841

Annotation

Keyword

Alternative splicing
Cell membrane
Cleavage on pair of basic residues
Direct protein sequencing
Disease variant
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q86SQ4	Developmentally regulated G-protein-coupled receptor G-protein coupled receptor 126 Vascular inducible G protein-coupled receptor

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
cell surface receptor signaling pathway	ISS
G protein-coupled receptor signaling pathway	TAS	15203201
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISS
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
nervous system development	TAS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cAMP-mediated signaling

ensheathment of neurons [inference]

axon ensheathment [inference]

peripheral nervous system axon ensheathment [inference]

myelination in peripheral nervous system

myelination

myelination in peripheral nervous system

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

Schwann cell differentiation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

trabecula formation [inference]

heart trabecula formation

anatomical structure development [inference]

system development [inference]

nervous system development

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

Schwann cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cAMP-mediated signaling

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GO Term	Evidence Code	PMID
cytoplasm	IDA	15189448
endoplasmic reticulum membrane	TAS
plasma membrane	IDA	15189448 24227709
plasma membrane	IBA
cell surface	IDA	15225624

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

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GO Term	Evidence Code	PMID
endopeptidase activity	TAS
G protein-coupled receptor activity	ISS
G protein-coupled receptor activity	IMP	24227709
G protein-coupled receptor activity	IBA
collagen binding	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

binding [inference]

protein binding [inference]

laminin binding

protein-containing complex binding [inference]

collagen binding

extracellular matrix binding

laminin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G-protein coupled receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
cell surface receptor signaling pathway

Displaying **all 4** entries
InterPro
GAIN domain superfamily
GPCR, family 2, secretin-like
GPCR, family 2-like, 7TM
GPS motif

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060558	lethal congenital contracture syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	57211	ZFIN:ZDB-GENE-041014-357
Mus musculus	215798	ZFIN:ZDB-GENE-041014-357	MOUSE02004
Rattus norvegicus	308376		RATNO17652
Pan troglodytes	463034		PANTR39209
Canis lupus familiaris	484013		CANLF00167
Bos taurus	534326		BOVIN35903
Danio rerio	561970	ZFIN:ZDB-GENE-041014-357
Macaca mulatta	706017		MACMU33386
Monodelphis domestica	100026302		MONDO14969
Equus caballus	100060706		HORSE29773

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements