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phosphoserine phosphatase

Summary

Gene Symbol

PSPH

Organism

Homo sapiens (human)

External Links

NCBI Gene

5723

HGNC

9577

PubChem

5723

Alliance of Genome Resources

HGNC:9577

JoGo

PSPH

TogoVar

PSPH

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Disease variant
Hydrolase
Magnesium
Metal-binding
Proteomics identification
Reference proteome
Serine biosynthesis

Proteins

Displaying 1 entry
UniProt	Protein Name
P78330	L-3-phosphoserine phosphatase O-phosphoserine phosphohydrolase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
in utero embryonic development	IEA
L-serine metabolic process	IDA	15291819
L-serine biosynthetic process	IMP	14673469
L-serine biosynthetic process	IBA
response to mechanical stimulus	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

L-serine metabolic process

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

L-serine metabolic process

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

L-serine metabolic process

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

L-serine metabolic process

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

L-serine metabolic process

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

L-serine metabolic process

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

L-serine metabolic process

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus

response to extracellular stimulus [inference]

response to nutrient levels

response to abiotic stimulus [inference]

response to mechanical stimulus

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

response to testosterone

response to lipid [inference]

response to testosterone

response to ketone [inference]

response to testosterone

response to oxygen-containing compound [inference]

response to ketone [inference]

response to testosterone

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytoplasm	IBA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	IDA	15291819
magnesium ion binding	IBA
L-phosphoserine phosphatase activity	IDA	15291819
L-phosphoserine phosphatase activity	IMP	14673469
L-phosphoserine phosphatase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

L-phosphoserine phosphatase activity

binding [inference]

protein binding [inference]

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Phosphoserine phosphatase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 5** entries
Gene Ontology
L-serine biosynthetic process
dephosphorylation
hydrolase activity
magnesium ion binding
metal ion binding

Displaying **all 3** entries
InterPro
HAD superfamily
HAD-like superfamily
Phosphoserine phosphatase

Human Protein Atlas

ENSG00000146733

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:21208

H₂O + O-phospho-L-serine

L-serine + phosphate

Enzyme

3.1.3.3

PMID

RHEA:24873

H₂O + O-phospho-D-serine

D-serine + phosphate

Enzyme

3.1.3.3

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050724	PSPH deficiency	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 24 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000047	Hypospadias
HP:0000154	Wide mouth
HP:0000252	Microcephaly
HP:0000293	Full cheeks
HP:0000337	Broad forehead
HP:0000341	Narrow forehead
HP:0000347	Micrognathia
HP:0001249	Intellectual disability
HP:0001250	Seizure