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phosphatase and tensin homolog

Summary

Gene Symbol

PTEN

Aliases

MMAC1
PTEN1
TEP1
mutated in multiple advanced cancers 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5728

HGNC

9588

KEGG Gene ID

hsa:5728

PubChem

5728

Alliance of Genome Resources

HGNC:9588

Annotation

Keyword

3D-structure
Acetylation
Alternative initiation
Alternative splicing
Apoptosis
Autism spectrum disorder
Cell projection
Cytoplasm
Disease variant
Isopeptide bond
Lipid metabolism
Lipid-binding
Neurogenesis
Nucleus
Phosphoprotein
Protein phosphatase
Reference proteome
Secreted
Synapse
Tumor suppressor
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P60484	Inositol polyphosphate 3-phosphatase Mutated in multiple advanced cancers 1 Phosphatase and tensin homolog
F6KD01	Phosphatase and tensin homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **36 - 40** of 61 in total

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GO Term	Evidence Code	PMID
phosphatidylinositol biosynthetic process	TAS
dendritic spine morphogenesis	ISS	18082964
negative regulation of cell cycle G1/S phase transition	IDA	10918569
prepulse inhibition	ISS	19208814
negative regulation of axonogenesis	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

dephosphorylation [inference]

protein dephosphorylation

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

meiotic spindle organization [inference]

meiotic spindle assembly [inference]

spindle assembly involved in female meiosis

spindle assembly [inference]

meiotic spindle assembly [inference]

spindle assembly involved in female meiosis

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

neuron-neuron synaptic transmission

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

cell death [inference]

programmed cell death [inference]

apoptotic process

cell cycle process [inference]

spindle organization [inference]

meiotic spindle organization [inference]

meiotic spindle assembly [inference]

spindle assembly involved in female meiosis

spindle assembly [inference]

meiotic spindle assembly [inference]

spindle assembly involved in female meiosis

meiotic cell cycle process [inference]

meiotic spindle organization [inference]

meiotic spindle assembly [inference]

spindle assembly involved in female meiosis

cellular process involved in reproduction in multicellular organism [inference]

spindle assembly involved in female meiosis

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

dephosphorylation [inference]

protein dephosphorylation

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cell motility

cell migration

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to electrical stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

meiotic spindle organization [inference]

meiotic spindle assembly [inference]

spindle assembly involved in female meiosis

spindle assembly [inference]

meiotic spindle assembly [inference]

spindle assembly involved in female meiosis

organelle assembly [inference]

postsynaptic specialization assembly [inference]

postsynaptic density assembly

non-membrane-bounded organelle assembly [inference]

spindle assembly [inference]

meiotic spindle assembly [inference]

spindle assembly involved in female meiosis

postsynaptic specialization organization [inference]

postsynaptic density organization [inference]

postsynaptic density assembly

postsynaptic specialization assembly [inference]

postsynaptic density assembly

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

organelle assembly [inference]

postsynaptic specialization assembly [inference]

postsynaptic density assembly

non-membrane-bounded organelle assembly [inference]

spindle assembly [inference]

meiotic spindle assembly [inference]

spindle assembly involved in female meiosis

membrane assembly [inference]

presynaptic membrane assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

central nervous system neuron axonogenesis

dendritic spine morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

dendritic spine morphogenesis

neuron projection organization [inference]

dendritic spine organization [inference]

dendritic spine morphogenesis

regulation of cellular component size [inference]

regulation of cell size [inference]

negative regulation of cell size

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

membrane organization [inference]

plasma membrane organization [inference]

myelin maintenance [inference]

central nervous system myelin maintenance

membrane assembly [inference]

presynaptic membrane assembly

presynaptic membrane organization [inference]

presynaptic membrane assembly

postsynapse organization [inference]

dendritic spine organization [inference]

dendritic spine morphogenesis

reproductive process [inference]

reproductive behavior [inference]

parental behavior [inference]

maternal behavior

cellular process involved in reproduction in multicellular organism [inference]

spindle assembly involved in female meiosis

meiotic cell cycle process [inference]

meiotic spindle organization [inference]

meiotic spindle assembly [inference]

spindle assembly involved in female meiosis

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

learning or memory

rhythmic behavior [inference]

circadian behavior [inference]

locomotor rhythm

locomotory behavior

locomotor rhythm

reproductive behavior [inference]

parental behavior [inference]

maternal behavior

multicellular organismal response to stress

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

central nervous system neuron axonogenesis

dendritic spine morphogenesis

forebrain morphogenesis

developmental maturation [inference]

synapse maturation

anatomical structure development [inference]

dentate gyrus development

animal organ development [inference]

heart development

system development [inference]

central nervous system development

rhythmic process [inference]

circadian rhythm [inference]

circadian behavior [inference]

locomotor rhythm

response to stimulus [inference]

response to stress [inference]

multicellular organismal response to stress

response to abiotic stimulus [inference]

response to electrical stimulus [inference]

cellular response to electrical stimulus

cellular response to abiotic stimulus [inference]

cellular response to electrical stimulus

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to electrical stimulus

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cellular senescence

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cellular senescence

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

regulation of peptidyl-serine phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cellular senescence [inference]

negative regulation of cellular senescence

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

regulation of peptidyl-serine phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

regulation of peptidyl-serine phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

regulation of peptidyl-serine phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

modulation of excitatory postsynaptic potential [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

rhythmic synaptic transmission

modulation of excitatory postsynaptic potential [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

neuron-neuron synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of synaptic vesicle clustering

regulation of synaptic vesicle clustering [inference]

negative regulation of synaptic vesicle clustering

regulation of growth [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of organ growth

regulation of developmental growth [inference]

regulation of organ growth [inference]

negative regulation of organ growth

negative regulation of developmental growth [inference]

negative regulation of organ growth

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of keratinocyte migration

negative regulation of wound healing, spreading of epidermal cells

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of keratinocyte migration

regulation of keratinocyte migration [inference]

negative regulation of keratinocyte migration

negative regulation of cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of keratinocyte migration

negative regulation of wound healing, spreading of epidermal cells

regulation of wound healing, spreading of epidermal cells [inference]

negative regulation of wound healing, spreading of epidermal cells

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of keratinocyte migration

negative regulation of wound healing, spreading of epidermal cells

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cellular senescence

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of keratinocyte migration

negative regulation of wound healing, spreading of epidermal cells

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of organ growth

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion [inference]

negative regulation of focal adhesion assembly

negative regulation of cell population proliferation

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cellular senescence

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of osteoblast differentiation

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis

negative regulation of cell-substrate junction organization [inference]

negative regulation of focal adhesion assembly

negative regulation of cell junction assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of keratinocyte migration

negative regulation of wound healing, spreading of epidermal cells

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of response to external stimulus [inference]

prepulse inhibition

negative regulation of wound healing [inference]

negative regulation of wound healing, spreading of epidermal cells

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of wound healing, spreading of epidermal cells

negative regulation of transport [inference]

negative regulation of synaptic vesicle clustering

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of osteoblast differentiation

negative regulation of developmental growth [inference]

negative regulation of organ growth

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of keratinocyte migration

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of excitatory postsynaptic potential

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

modulation of excitatory postsynaptic potential [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

negative regulation of wound healing [inference]

negative regulation of wound healing, spreading of epidermal cells

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of response to external stimulus [inference]

prepulse inhibition

negative regulation of wound healing [inference]

negative regulation of wound healing, spreading of epidermal cells

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of wound healing, spreading of epidermal cells

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

negative regulation of wound healing [inference]

negative regulation of wound healing, spreading of epidermal cells

regulation of wound healing, spreading of epidermal cells [inference]

negative regulation of wound healing, spreading of epidermal cells

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of wound healing, spreading of epidermal cells

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

negative regulation of axonogenesis

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of osteoblast differentiation

regulation of osteoblast differentiation [inference]

negative regulation of osteoblast differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

regulation of developmental growth [inference]

regulation of organ growth [inference]

negative regulation of organ growth

negative regulation of developmental growth [inference]

negative regulation of organ growth

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of osteoblast differentiation

negative regulation of developmental growth [inference]

negative regulation of organ growth

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

modulation of excitatory postsynaptic potential [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

rhythmic synaptic transmission

modulation of excitatory postsynaptic potential [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion [inference]

negative regulation of focal adhesion assembly

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

negative regulation of cell-matrix adhesion [inference]

negative regulation of focal adhesion assembly

regulation of focal adhesion assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion [inference]

negative regulation of focal adhesion assembly

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cellular senescence

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

regulation of peptidyl-serine phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cellular senescence [inference]

negative regulation of cellular senescence

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

negative regulation of cell population proliferation

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of vascular associated smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of cell junction assembly [inference]

negative regulation of focal adhesion assembly

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of osteoblast differentiation

regulation of osteoblast differentiation [inference]

negative regulation of osteoblast differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion [inference]

negative regulation of focal adhesion assembly

negative regulation of cell population proliferation

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of peptidyl-serine phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cellular senescence

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of osteoblast differentiation

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis

negative regulation of cell-substrate junction organization [inference]

negative regulation of focal adhesion assembly

negative regulation of cell junction assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of keratinocyte migration

negative regulation of wound healing, spreading of epidermal cells

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development

negative regulation of neuron projection development

negative regulation of axonogenesis

regulation of axonogenesis [inference]

negative regulation of axonogenesis

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis

negative regulation of cell-substrate junction organization [inference]

negative regulation of focal adhesion assembly

negative regulation of cell junction assembly [inference]

negative regulation of focal adhesion assembly

regulation of cell-substrate junction organization [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of cell-substrate junction organization [inference]

negative regulation of focal adhesion assembly

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly [inference]

negative regulation of focal adhesion assembly

negative regulation of cell junction assembly [inference]

negative regulation of focal adhesion assembly

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle phase transition [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition

negative regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle G1/S phase transition [inference]

negative regulation of cell cycle G1/S phase transition

negative regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of keratinocyte migration

regulation of keratinocyte migration [inference]

negative regulation of keratinocyte migration

negative regulation of cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of keratinocyte migration

negative regulation of wound healing, spreading of epidermal cells

regulation of wound healing, spreading of epidermal cells [inference]

negative regulation of wound healing, spreading of epidermal cells

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of keratinocyte migration

negative regulation of wound healing, spreading of epidermal cells

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of keratinocyte migration

regulation of keratinocyte migration [inference]

negative regulation of keratinocyte migration

regulation of system process [inference]

regulation of nervous system process [inference]

modulation of excitatory postsynaptic potential [inference]

regulation of organ growth [inference]

negative regulation of organ growth

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of keratinocyte migration

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

regulation of biological quality [inference]

regulation of protein stability

protein stabilization

regulation of membrane potential [inference]

modulation of excitatory postsynaptic potential [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

negative regulation of cell size

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

positive regulation of DNA-binding transcription factor activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

positive regulation of transferase activity [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein kinase activity [inference]

negative regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin-protein transferase activity [inference]

positive regulation of ubiquitin protein ligase activity

regulation of ubiquitin protein ligase activity [inference]

positive regulation of ubiquitin protein ligase activity

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
postsynaptic density	IEA
apical plasma membrane	IMP	24862762
myelin sheath adaxonal region	ISS
plasma membrane	IBA IDA	10760291
cell projection	IBA IDA	10760291 25007873

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

nuclear body [inference]

PML body

myelin sheath adaxonal region

cell projection

plasma membrane bounded cell projection [inference]

neuron projection

neuron spine [inference]

dendritic spine

Schmidt-Lanterman incisure

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

postsynaptic specialization [inference]

postsynaptic density

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

postsynapse [inference]

dendritic spine

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GO Term	Evidence Code	PMID
phosphatidylinositol phosphate phosphatase activity	IDA	9811831
protein binding	IPI	15355975 15951562 16456542 17242191 17274640 18716620 19345329 19369943 19473982 19903340 21241890 21593423 21653829 21804599 23514585 23940795 24012959 24656772 25007873 25241761 26280536 36950384
enzyme binding	IPI	16845383
molecular function inhibitor activity	IMP	23744781
protein tyrosine phosphatase activity	IBA IDA	9256433

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity

protein serine/threonine phosphatase activity

myosin phosphatase activity

protein tyrosine phosphatase activity

inositol phosphate phosphatase activity [inference]

inositol tetrakisphosphate phosphatase activity [inference]

inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity

inositol pentakisphosphate phosphatase activity [inference]

inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity

phosphatidylinositol phosphate phosphatase activity

phosphatidylinositol bisphosphate phosphatase activity [inference]

phosphatidylinositol-3,4-bisphosphate phosphatase activity [inference]

phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity

phosphatidylinositol trisphosphate phosphatase activity [inference]

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

phosphatidylinositol monophosphate phosphatase activity [inference]

phosphatidylinositol-3-phosphate phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity

protein serine/threonine phosphatase activity

myosin phosphatase activity

protein tyrosine phosphatase activity

binding [inference]

protein binding

enzyme binding

protease binding [inference]

ubiquitin-specific protease binding

protein domain specific binding [inference]

PDZ domain binding

identical protein binding

lipid binding

protein-containing complex binding [inference]

anaphase-promoting complex binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

ubiquitin-protein transferase activator activity [inference]

ubiquitin ligase activator activity

ubiquitin-protein transferase regulator activity [inference]

ubiquitin-protein transferase activator activity [inference]

ubiquitin ligase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

ubiquitin-protein transferase activator activity [inference]

ubiquitin ligase activator activity

molecular function inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

phosphatase

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
cell motility
dephosphorylation
negative regulation of cell population proliferation
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
protein tyrosine phosphatase activity
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Displaying **all 4** entries
InterPro
Protein-tyrosine phosphatase, active site
Protein-tyrosine phosphatase-like
Tensin-type phosphatase domain
Tyrosine-specific protein phosphatases domain

Human Protein Atlas

ENSG00000171862

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01110

Name

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]

References

Rhea

RHEA:20629

H₂O

phosphate

Enzyme

3.1.3.16

PMID

RHEA:47004

H₂O

phosphate

Enzyme

3.1.3.16

PMID

RHEA:10684

H₂O

phosphate

Enzyme

3.1.3.48

PMID

RHEA:25017

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)

phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

Enzyme

3.1.3.67

PMID

Disease

Disease Ontology

Displaying entries **51 - 53** of 53 in total

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DO ID	Disease Name	Source
DOID:9408	acute myocardial infarction	Alliance of Genome Resources
DOID:9452	steatotic liver disease	Alliance of Genome Resources
DOID:9952	acute lymphoblastic leukemia	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0100026	Arteriovenous malformation
HP:0100031	Neoplasm of the thyroid gland
HP:0100521	Neoplasm of the thymus
HP:0100526	Neoplasm of the lung
HP:0100543	Cognitive impairment
HP:0100555	Asymmetric growth
HP:0100559	Lower limb asymmetry
HP:0100560	Upper limb asymmetry
HP:0100579	Mucosal telangiectasiae
HP:0100615	Ovarian neoplasm

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Disease ID	Disease Name
OMIM:605309	macrocephaly-autism syndrome
OMIM:176807	familial prostate carcinoma
ORPHA:65285	Cowden syndrome 1 Lhermitte-Duclos disease
ORPHA:210548	macrocephaly-autism syndrome
OMIM:613028	glioma susceptibility 2
ORPHA:2969	Cowden syndrome 1 Proteus-like syndrome
OMIM:607174	familial meningioma
ORPHA:109	Bannayan-Riley-Ruvalcaba syndrome
ORPHA:137608	segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome
ORPHA:397596	activated PI3K-delta syndrome

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000810
Gene Name: phosphatase and tensin homolog

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	19211		MGI:109583	MOUSE25368
Drosophila melanogaster	43991		FB:FBgn0026379
Rattus norvegicus	50557		RGD:61995	RATNO20306
Caenorhabditis elegans	176869		WB:WBGene00000913
Danio rerio	368415		ZFIN:ZDB-GENE-030616-47
Xenopus laevis	399142		Xenbase:XB-GENE-491437
Canis lupus familiaris	403832			CANLF10667
Pan troglodytes	466142	9598_0:002bec		PANTR01087
Bos taurus	540786			BOVIN21124
Danio rerio	794088		ZFIN:ZDB-GENE-030131-3776

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements