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phosphatase and tensin homolog
Summary
- Gene Symbol
-
- PTEN
- Aliases
-
- MMAC1
- PTEN1
- TEP1
- mutated in multiple advanced cancers 1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative initiation
- Alternative splicing
- Apoptosis
- Autism spectrum disorder
- Cell projection
- Cytoplasm
- Disease variant
- Isopeptide bond
- Lipid metabolism
- Lipid-binding
- Neurogenesis
- Nucleus
- Phosphoprotein
- Protein phosphatase
- Reference proteome
- Secreted
- Synapse
- Tumor suppressor
- Ubl conjugation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of protein phosphorylation |
|
|
| chromatin remodeling | ||
| protein dephosphorylation | ||
| protein dephosphorylation | ||
| phosphatidylinositol biosynthetic process |
GO Hierarchy
- negative regulation of excitatory postsynaptic potential
biological process
metabolic process [inference]
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
negative regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
negative regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cell cycle [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane | ||
| plasma membrane | ||
| cytoplasmic side of plasma membrane | ||
| postsynaptic density | ||
| apical plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| phosphatidylinositol-3-phosphate phosphatase activity | ||
| phosphoprotein phosphatase activity | ||
| protein serine/threonine phosphatase activity | ||
| protein tyrosine phosphatase activity | ||
| protein tyrosine phosphatase activity |
GO Hierarchy
- RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
- RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
- RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
- RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
- RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
- myosin phosphatase activity
- MAP kinase serine/threonine phosphatase activity
- RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
- RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
- RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
- RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
- RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
- myosin phosphatase activity
- MAP kinase serine/threonine phosphatase activity
- RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
- RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
- RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
- RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
- RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
molecular function
catalytic activity [inference]
hydrolase activity [inference]
hydrolase activity, acting on ester bonds [inference]
phosphoric ester hydrolase activity [inference]
phosphatase activity [inference]
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
RNA polymerase II CTD heptapeptide repeat phosphatase activity [inference]
catalytic activity, acting on a protein [inference]
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
RNA polymerase II CTD heptapeptide repeat phosphatase activity [inference]
RNA polymerase II CTD heptapeptide repeat modifying activity [inference]
RNA polymerase II CTD heptapeptide repeat phosphatase activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- phosphatase
- Functional Category
-
- G: Carbohydrate transport and metabolism
- P: Inorganic ion transport and metabolism
- T: Signal transduction mechanisms
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050657 | Bannayan-Riley-Ruvalcaba syndrome | |
| DOID:0060867 | macrocephaly-autism syndrome | |
| DOID:0080191 | PTEN hamartoma tumor syndrome | |
| DOID:10283 | prostate cancer | |
| DOID:11054 | urinary bladder cancer | |
| DOID:1192 | peripheral nervous system neoplasm | |
| DOID:1612 | breast cancer | |
| DOID:2394 | ovarian cancer | |
| DOID:2938 | Epstein-Barr virus infectious disease | |
| DOID:3070 | high grade glioma |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000486 | Strabismus |
| HP:0000494 | Downslanted palpebral fissures |
| HP:0000501 | Glaucoma |
| HP:0000508 | Ptosis |
| HP:0000518 | Cataract |
| HP:0000520 | Proptosis |
| HP:0000541 | Retinal detachment |
| HP:0000545 | Myopia |
| HP:0000557 | Buphthalmos |
| HP:0000565 | Esotropia |
| Disease ID | Disease Name |
|---|---|
| ORPHA:109 |
|
| ORPHA:137608 |
|
| ORPHA:101070 |
|
| ORPHA:2969 |
|
| OMIM:607174 |
|
| ORPHA:79076 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP000810
- Gene Name
- phosphatase and tensin homolog
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 5728 | Xenbase:XB-GENE-491433 | ||
| 19211 | MOUSE25368 | ||
| 50557 | RATNO20306 | ||
| 403832 | CANLF10667 | ||
| 466142 | PANTR01087 | ||
| 540786 | BOVIN21124 | ||
| 100062388 | HORSE16191 | ||
| 100171828 | PONAB01020 | ||
| 100182434 | CIOIN12576 | ||
| 100358716 | RABIT06803 |
