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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
phosphatase and tensin homolog
Summary
- Gene Symbol
-
- PTEN
- Aliases
-
- MMAC1
- PTEN1
- TEP1
- mutated in multiple advanced cancers 1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative initiation
- Alternative splicing
- Apoptosis
- Autism spectrum disorder
- Cell projection
- Cytoplasm
- Disease variant
- Isopeptide bond
- Lipid metabolism
- Lipid-binding
- Neurogenesis
- Nucleus
- Phosphoprotein
- Protein phosphatase
- Reference proteome
- Secreted
- Synapse
- Tumor suppressor
- Ubl conjugation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of protein stability | ||
| positive regulation of cell population proliferation | ||
| negative regulation of protein phosphorylation | ||
| negative regulation of keratinocyte migration | ||
| protein stabilization |
GO Hierarchy
- negative regulation of excitatory postsynaptic potential
biological process
metabolic process [inference]
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of phosphorus metabolic process [inference]
negative regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of phosphorus metabolic process [inference]
negative regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cell cycle [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| postsynaptic density | ||
| apical plasma membrane | ||
| myelin sheath adaxonal region | ||
| plasma membrane | ||
| cell projection |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| phosphatidylinositol phosphate phosphatase activity | ||
| protein binding | ||
| enzyme binding | ||
| molecular function inhibitor activity | ||
| protein tyrosine phosphatase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- phosphatase
- Functional Category
-
- E: Amino acid transport and metabolism
- P: Inorganic ion transport and metabolism
- T: Signal transduction mechanisms
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1470 | major depressive disorder | |
| DOID:1612 | breast cancer | |
| DOID:162 | cancer | |
| DOID:2018 | hyperinsulinism | |
| DOID:219 | colon cancer | |
| DOID:224 | transient cerebral ischemia | |
| DOID:2394 | ovarian cancer | |
| DOID:264 | hemangiopericytoma | |
| DOID:2938 | Epstein-Barr virus infectious disease | |
| DOID:303 | substance-related disorder |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001442 | Typified by somatic mosaicism |
| HP:0001482 | Subcutaneous nodule |
| HP:0001508 | Failure to thrive |
| HP:0001513 | Obesity |
| HP:0001519 | Disproportionate tall stature |
| HP:0001520 | Large for gestational age |
| HP:0001548 | Overgrowth |
| HP:0001555 | Asymmetry of the thorax |
| HP:0001597 | Abnormality of the nail |
| HP:0001627 | Abnormal heart morphology |
| Disease ID | Disease Name |
|---|---|
| OMIM:605309 |
|
| OMIM:176807 |
|
| ORPHA:65285 |
|
| ORPHA:210548 |
|
| OMIM:613028 |
|
| ORPHA:2969 |
|
| OMIM:607174 |
|
| ORPHA:109 |
|
| ORPHA:137608 |
|
| ORPHA:397596 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP000810
- Gene Name
- phosphatase and tensin homolog
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 855595 | SGD:S000005072 | |||
| 100062388 | HORSE16191 | |||
| 100144716 | Xenbase:XB-GENE-491433 | |||
| 100171828 | 9601_0:002b0f | PONAB01020 | ||
| 100182434 | CIOIN12576 | |||
| 100358716 | RABIT06803 | |||
| 100469483 | AILME17675 | |||
| 100505440 | Xenbase:XB-GENE-17342770 | |||
| 100552870 | ANOCA16519 | |||
| 100605147 | NOMLE26489 |
