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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
phosphatase and tensin homolog
Summary
- Gene Symbol
-
- PTEN
- Aliases
-
- MMAC1
- PTEN1
- TEP1
- mutated in multiple advanced cancers 1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative initiation
- Alternative splicing
- Apoptosis
- Autism spectrum disorder
- Cell projection
- Cytoplasm
- Disease variant
- Isopeptide bond
- Lipid metabolism
- Lipid-binding
- Neurogenesis
- Nucleus
- Phosphoprotein
- Protein phosphatase
- Reference proteome
- Secreted
- Synapse
- Tumor suppressor
- Ubl conjugation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of protein stability | ||
| positive regulation of cell population proliferation | ||
| negative regulation of protein phosphorylation | ||
| negative regulation of keratinocyte migration | ||
| protein stabilization |
GO Hierarchy
- negative regulation of excitatory postsynaptic potential
biological process
metabolic process [inference]
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of phosphorus metabolic process [inference]
negative regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of phosphorus metabolic process [inference]
negative regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cell cycle [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| postsynaptic density | ||
| apical plasma membrane | ||
| myelin sheath adaxonal region | ||
| plasma membrane | ||
| cell projection |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| phosphatidylinositol phosphate phosphatase activity | ||
| protein binding | ||
| enzyme binding | ||
| molecular function inhibitor activity | ||
| protein tyrosine phosphatase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- phosphatase
- Functional Category
-
- E: Amino acid transport and metabolism
- P: Inorganic ion transport and metabolism
- T: Signal transduction mechanisms
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:3070 | high grade glioma | |
| DOID:3314 | angiomyolipoma | |
| DOID:3742 | bladder squamous cell carcinoma | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:3962 | thyroid gland follicular carcinoma | |
| DOID:4450 | renal cell carcinoma | |
| DOID:4586 | familial meningioma | |
| DOID:4928 | intrahepatic cholangiocarcinoma | |
| DOID:5041 | esophageal cancer | |
| DOID:6457 | Cowden syndrome |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000957 | Cafe-au-lait spot |
| HP:0000965 | Cutis marmorata |
| HP:0000972 | Palmoplantar hyperkeratosis |
| HP:0000973 | Cutis laxa |
| HP:0000982 | Palmoplantar keratoderma |
| HP:0000995 | Melanocytic nevus |
| HP:0001000 | Abnormality of skin pigmentation |
| HP:0001004 | Lymphedema |
| HP:0001009 | Telangiectasia |
| HP:0001012 | Multiple lipomas |
| Disease ID | Disease Name |
|---|---|
| OMIM:605309 |
|
| OMIM:176807 |
|
| ORPHA:65285 |
|
| ORPHA:210548 |
|
| OMIM:613028 |
|
| ORPHA:2969 |
|
| OMIM:607174 |
|
| ORPHA:109 |
|
| ORPHA:137608 |
|
| ORPHA:397596 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP000810
- Gene Name
- phosphatase and tensin homolog
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 109108030 | CYPCA100830 | |||
| 109312531 | CROPO21604 | |||
| 110199935 | PHACI19695 | |||
| 112931976 | VULVU27621 | |||
| 113449026 | PSETE22795 | |||
| 113481870 | ATHCN18503 | |||
| 113579468 | ELEEL24333 | |||
| 113884568 | BOBOX20632 | |||
| 114597278 | PODMU36285 | |||
| 115055427 | ECHNA11732 |
