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gremlin 1, DAN family BMP antagonist

Summary

Gene Symbol

GREM1

Organism

Macaca mulatta (Rhesus monkey)

External Links

NCBI Gene: 574176
PubChem: 574176

Annotation

Keyword

Cytokine
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
G7MW95
Q8WNY1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
animal organ morphogenesis	IEA	30032202
negative regulation of BMP signaling pathway
sequestering of BMP from receptor via BMP binding	IEA	30032202
negative regulation of osteoblast differentiation

GO Hierarchy

biological process

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cell differentiation [inference]

negative regulation of osteoblast differentiation

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of osteoblast differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of osteoblast differentiation

regulation of osteoblast differentiation [inference]

negative regulation of osteoblast differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of osteoblast differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of osteoblast differentiation

regulation of osteoblast differentiation [inference]

negative regulation of osteoblast differentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP from receptor via BMP binding

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP from receptor via BMP binding

negative regulation of cell differentiation [inference]

negative regulation of osteoblast differentiation

Displaying 1 entry
GO Term	Evidence Code	PMID
extracellular space	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytokine activity
BMP binding	IEA	30032202
receptor ligand activity	IEA	30032202

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity

cytokine activity

cytokine binding [inference]

BMP binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

gremlin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
BMP binding
animal organ morphogenesis
sequestering of BMP from receptor via BMP binding

Displaying **all 3** entries
InterPro
Cystine knot, C-terminal
Cystine-knot cytokine
DAN

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	Orthologous MAtrix
Mus musculus	23892	MOUSE35514
Rattus norvegicus	50566	RATNO27271
Danio rerio	100005728	DANRE11743
Monodelphis domestica	100031599	MONDO04703
Sus scrofa	100156280	PIGXX14677
Oryctolagus cuniculus	100342066	RABIT06209
Callithrix jacchus	100401905	CALJA01020
Pongo abelii	100460446	PONAB08750
Meleagris gallopavo	100543773	MELGA10907
Anolis carolinensis	100561932	ANOCA00230