prostaglandin-endoperoxide synthase 2

Summary
Gene Symbol
  • PTGS2
Aliases
  • COX2
  • cyclooxygenase 2
  • prostaglandin G/H synthase 2
Organism
Homo sapiens (human)
External Links
NCBI Gene
5743
HGNC
9605
KEGG Gene ID
hsa:5743
PubChem
5743
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Acetylation
  • Dioxygenase
  • Disulfide bond
  • Glycoprotein
  • Heme
  • Membrane
  • Microsome
  • Nucleus
  • Peroxidase
  • Prostaglandin biosynthesis
  • Reference proteome
  • S-nitrosylation
  • Signal
Proteins
Displaying 1 entry
UniProt Protein Name
P35354
  • Cyclooxygenase-2
  • PHS II
  • Prostaglandin H2 synthase 2
  • Prostaglandin-endoperoxide synthase 2
Gene Ontology (GO)
GO Hierarchy
Human Protein Atlas
ENSG00000073756

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K11987
Name
prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
References
Disease
Disease Ontology
Displaying entries 51 - 60 of 958 in total
DO ID Disease Name Source
DOID:0060192 Crohn's colitis
DOID:0060224 atrial fibrillation
DOID:0060239 Van der Woude syndrome
DOID:0060262 gallbladder disease
DOID:0060318 acute promyelocytic leukemia
DOID:0060319 cardiac arrest
DOID:0060389 chromosome 10q23 deletion syndrome
DOID:0060479 Shwachman-Diamond syndrome
DOID:0060597 atypical chronic myeloid leukemia, BCR-ABL1 negative
DOID:0060600 obsolete hereditary motor and sensory neuropathy with agenesis of the corpus callosum
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP000761
Gene Name
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024