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alanyl-tRNA synthetase 2, mitochondrial

Summary

Gene Symbol

AARS2

Organism

Homo sapiens (human)

External Links

NCBI Gene

57505

PubChem

57505

Alliance of Genome Resources

HGNC:21022

JoGo

AARS2

TogoVar

AARS2

Annotation

Keyword

3D-structure
ATP-binding
Aminoacyl-tRNA synthetase
Cardiomyopathy
Disease variant
Metal-binding
Mitochondrion
Neurodegeneration
Premature ovarian failure
Primary mitochondrial disease
Protein biosynthesis
Proteomics identification
Reference proteome
Transit peptide
Zinc
tRNA-binding

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5JTZ9	Alanyl-tRNA synthetase Protein lactyltransferase AARS2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
alanyl-tRNA aminoacylation	IBA
mitochondrial alanyl-tRNA aminoacylation	IMP	21549344
aminoacyl-tRNA metabolism involved in translational fidelity	IEA
negative regulation of cGAS/STING signaling pathway	IDA	39322678

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of response to external stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of biological quality [inference]

regulation of translational fidelity [inference]

aminoacyl-tRNA metabolism involved in translational fidelity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrion	IDA	21549344
mitochondrion	IBA
mitochondrion	HTP	34800366

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 7 in total

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Last »
GO Term	Evidence Code	PMID
tRNA binding	IEA
aminoacyl-tRNA editing activity	IBA
alanine-tRNA ligase activity	IMP	21549344
alanine-tRNA ligase activity	IBA
protein binding	IPI	32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

aminoacyl-tRNA editing activity

ligase activity [inference]

ligase activity, forming carbon-oxygen bonds [inference]

aminoacyl-tRNA ligase activity [inference]

alanine-tRNA ligase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

aminoacyl-tRNA editing activity

aminoacyl-tRNA ligase activity [inference]

alanine-tRNA ligase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

tRNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070396	progressive leukoencephalopathy with ovarian failure	Alliance of Genome Resources
DOID:0111479	combined oxidative phosphorylation deficiency 8	Alliance of Genome Resources

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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