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DEAH-box helicase 37

Summary

Gene Symbol

DHX37

Organism

Homo sapiens (human)

External Links

NCBI Gene

57647

PubChem

57647

Alliance of Genome Resources

HGNC:17210

Annotation

Keyword

3D-structure
Cytoplasm
Disease variant
Helicase
Intellectual disability
Membrane
Nucleus
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IY37	DEAH box protein 37

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
brain development	IMP	31256877
ribosome biogenesis	IDA	30582406
ribosome assembly	IDA	30582406
ribosomal small subunit biogenesis	IDA	34516797

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

ribosome assembly

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

ribosome assembly

cellular component biogenesis [inference]

ribonucleoprotein complex biogenesis [inference]

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of gonad development [inference]

positive regulation of male gonad development

positive regulation of multicellular organismal process [inference]

positive regulation of gonad development [inference]

positive regulation of male gonad development

positive regulation of reproductive process [inference]

positive regulation of gonad development [inference]

positive regulation of male gonad development

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of gonad development [inference]

positive regulation of male gonad development

regulation of gonad development [inference]

positive regulation of gonad development [inference]

positive regulation of male gonad development

regulation of male gonad development [inference]

positive regulation of male gonad development

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of gonad development [inference]

positive regulation of male gonad development

regulation of reproductive process [inference]

regulation of gonad development [inference]

positive regulation of gonad development [inference]

positive regulation of male gonad development

regulation of male gonad development [inference]

positive regulation of male gonad development

positive regulation of reproductive process [inference]

positive regulation of gonad development [inference]

positive regulation of male gonad development

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleoplasm	TAS
nucleolus	IDA	31337883
nucleolus	IBA
cytoplasm	IDA	31337883
nuclear membrane	IDA	31337883

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex [inference]

preribosome [inference]

small-subunit processome

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

nuclear membrane

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
DNA clamp loader activity
RNA binding	IBA
RNA helicase activity	IEA
helicase activity	IBA
protein binding	IPI	30582406

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a protein [inference]

ATP-dependent histone chaperone activity [inference]

catalytic activity, acting on a nucleic acid [inference]

helicase activity

RNA helicase activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA clamp loader activity

DNA translocase activity [inference]

chromatin extrusion motor activity

ATP-dependent chromatin remodeler activity [inference]

ATP-dependent histone chaperone activity [inference]

cohesin loader activity

catalytic activity, acting on RNA [inference]

RNA helicase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

snoRNA binding [inference]

U3 snoRNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular carrier activity [inference]

protein carrier chaperone [inference]

histone chaperone activity [inference]

H3-H4 histone complex chaperone activity [inference]

ATP-dependent H3-H4 histone complex chaperone activity

ATP-dependent histone chaperone activity [inference]

ATP-dependent activity [inference]

helicase activity

RNA helicase activity

ATP-dependent activity, acting on DNA [inference]

DNA clamp loader activity

DNA translocase activity [inference]

chromatin extrusion motor activity

ATP-dependent chromatin remodeler activity [inference]

ATP-dependent histone chaperone activity [inference]

ATP-dependent activity, acting on RNA [inference]

RNA helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

atp-dependent rna helicase

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis

Displaying **all 2** entries
Gene Ontology
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
DEAD-box helicase, OB fold
DEAD/DEAH box helicase domain
Helicase superfamily 1/2, ATP-binding domain
Helicase, C-terminal domain-like
Helicase-associated domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14448	46,XY complete gonadal dysgenesis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	57647	Xenbase:XB-GENE-5765747
Mus musculus	208144		MOUSE44929
Rattus norvegicus	288647		RATNO06051
Pan troglodytes	452413		PANTR07245
Canis lupus familiaris	477442		CANLF10234
Bos taurus	529207		BOVIN09360
Macaca mulatta	706709		MACMU02988
Danio rerio	100009635		DANRE43228
Monodelphis domestica	100029494		MONDO18018
Equus caballus	100059323		HORSE41120

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Acknowledgements