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hyperpolarization activated cyclic nucleotide gated potassium channel 3

Summary

Gene Symbol

HCN3

Organism

Homo sapiens (human)

External Links

NCBI Gene

57657

PubChem

57657

Alliance of Genome Resources

HGNC:19183

Annotation

Keyword

3D-structure
Cell membrane
Glycoprotein
Ligand-gated ion channel
Phosphoprotein
Potassium channel
Proteomics identification
Reference proteome
Sodium channel
Transmembrane helix
Voltage-gated channel
cAMP-binding

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9P1Z3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
regulation of membrane depolarization	IDA	16043489
regulation of membrane depolarization	IBA
sodium ion transmembrane transport	IDA	16043489
sodium ion transmembrane transport	IMP	22748890
sodium ion transmembrane transport	IBA

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

response to stimulus [inference]

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

response to monoamine [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

response to dopamine [inference]

cellular response to dopamine

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

response to dopamine [inference]

cellular response to dopamine

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

response to monoamine [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

response to dopamine [inference]

cellular response to dopamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

response to oxygen-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

response to dopamine [inference]

cellular response to dopamine

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

sodium ion transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of membrane depolarization

regulation of cell communication [inference]

regulation of SA node cell action potential

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of SA node cell action potential

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of membrane potential

regulation of membrane depolarization

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of SA node cell action potential

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	22748890
axon	IBA
dendrite	IBA
neuronal cell body	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex [inference]

HCN channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex [inference]

HCN channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex [inference]

HCN channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus [inference]

cone cell pedicle

presynapse [inference]

axon terminus [inference]

cone cell pedicle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
voltage-gated sodium channel activity	IDA	16043489
voltage-gated sodium channel activity	IMP	22748890
voltage-gated potassium channel activity	IDA	16043489
voltage-gated potassium channel activity	IMP	22748890
voltage-gated potassium channel activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

cyclic nucleotide binding [inference]

cAMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

ion binding [inference]

anion binding [inference]

cAMP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

cyclic nucleotide binding [inference]

cAMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 5** entries
Gene Ontology
monoatomic ion channel activity
monoatomic ion transport
regulation of membrane depolarization
sodium ion transmembrane transport
voltage-gated potassium channel activity