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Guidelines

MIRAGE

protein tyrosine phosphatase non-receptor type 7

Summary

Gene Symbol

PTPN7

Organism

Homo sapiens (human)

External Links

NCBI Gene

5778

PubChem

5778

Alliance of Genome Resources

HGNC:9659

Annotation

Keyword

3D-structure
Alternative splicing
Cytoskeleton
Oxidation
Phosphoprotein
Protein phosphatase
Receptor
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P35236	Hematopoietic protein-tyrosine phosphatase Protein-tyrosine phosphatase LC-PTP
B4DZD9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein dephosphorylation	TAS	1530918
signal transduction	IBA
chromatin remodeling	IEA
MAPK cascade	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular process [inference]

signal transduction

intracellular signal transduction [inference]

MAPK cascade

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

intracellular signal transduction [inference]

MAPK cascade

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	10940933 14613483
nucleoplasm	TAS
cytosol	IDA TAS	10940933
microtubule cytoskeleton	IDA
cytoplasmic side of plasma membrane	IDA	10940933

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
non-membrane spanning protein tyrosine phosphatase activity	TAS
protein tyrosine phosphatase activity	IBA
protein binding	IPI	10415025 12583813 12592337 25241761 25416956 32296183
histone H2AXY142 phosphatase activity	IEA
protein tyrosine phosphatase activity, metal-dependent	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

histone modifying activity [inference]

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	5770	SGD:S000002389
Saccharomyces cerevisiae S288C	5771	SGD:S000002389
Saccharomyces cerevisiae S288C	5778	SGD:S000000877
Caenorhabditis elegans	5793	WB:WBGene00021702
Caenorhabditis elegans	5803	WB:WBGene00021702
Drosophila melanogaster	19259	FB:FBgn0016641
Saccharomyces cerevisiae S288C	19264	SGD:S000000877
Saccharomyces cerevisiae S288C	19266	SGD:S000000877
Saccharomyces cerevisiae S288C	19268	SGD:S000000877
Saccharomyces cerevisiae S288C	19270	SGD:S000000877

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GlyCosmos Portal v4.1.1

Last updated: February 17, 2025