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Guidelines

MIRAGE

protein tyrosine phosphatase non-receptor type 7

Summary

Gene Symbol

PTPN7

Organism

Homo sapiens (human)

External Links

NCBI Gene

5778

PubChem

5778

Alliance of Genome Resources

HGNC:9659

Annotation

Keyword

3D-structure
Alternative splicing
Cytoskeleton
Oxidation
Phosphoprotein
Protein phosphatase
Proteomics identification
Receptor
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P35236	Hematopoietic protein-tyrosine phosphatase Protein-tyrosine phosphatase LC-PTP
B4DZD9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
MAPK cascade	TAS
chromatin remodeling	IEA
protein dephosphorylation	TAS	1530918
signal transduction	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular process [inference]

signal transduction

intracellular signal transduction [inference]

MAPK cascade

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

intracellular signal transduction [inference]

MAPK cascade

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
nucleoplasm	TAS
cytoplasm	IDA	10940933 14613483
cytosol	TAS
cytosol	IDA	10940933
cytoplasmic side of plasma membrane	IDA	10940933

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein tyrosine phosphatase activity	IBA
non-membrane spanning protein tyrosine phosphatase activity	TAS
protein binding	IPI	10415025 12583813 12592337 25241761 25416956 32296183
protein tyrosine phosphatase activity, metal-dependent	IEA
histone H2AXY142 phosphatase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

histone modifying activity [inference]

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Receptor-type tyrosine-protein phosphatase T

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
dephosphorylation
protein kinase binding
protein tyrosine phosphatase activity

Displaying **all 6** entries
InterPro
Protein-tyrosine phosphatase, KIM-containing
Protein-tyrosine phosphatase, active site
Protein-tyrosine phosphatase, catalytic
Protein-tyrosine phosphatase-like
Tyrosine-specific protein phosphatase, PTPase domain
Tyrosine-specific protein phosphatases domain

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025