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Guidelines

MIRAGE

3-hydroxyacyl-CoA dehydratase 3

Summary

Gene Symbol

Hacd3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

57874

PubChem

57874

Alliance of Genome Resources

MGI:1889341

Annotation

Keyword

Acetylation
Coiled coil
Endoplasmic reticulum
Fatty acid biosynthesis
Lyase
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8K2C9	3-hydroxyacyl-CoA dehydratase 3 Butyrate-induced protein 1 Protein-tyrosine phosphatase-like A domain-containing protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
JNK cascade	IDA	10747961
Rho protein signal transduction	IDA	10747961
sphingolipid biosynthetic process	IBA
fatty acid elongation	ISS
fatty acid elongation	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process [inference]

very long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process [inference]

very long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process [inference]

very long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process [inference]

very long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process [inference]

very long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process [inference]

very long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process [inference]

very long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process [inference]

very long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

positive regulation of biological process [inference]

positive regulation of viral process [inference]

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of viral process [inference]

regulation by virus of viral protein levels in host cell [inference]

positive regulation by virus of viral protein levels in host cell

positive regulation of viral process [inference]

regulation of viral life cycle [inference]

regulation of viral genome replication [inference]

positive regulation of viral genome replication

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of biological quality [inference]

regulation by virus of viral protein levels in host cell [inference]

positive regulation by virus of viral protein levels in host cell

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	ISS
endoplasmic reticulum	ISO
endoplasmic reticulum membrane	IBA
endoplasmic reticulum membrane	IEA
nuclear membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	10747961 25036637
3-hydroxyacyl-CoA dehydratase activity	IBA
enzyme binding	ISS
enzyme binding	ISO
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

enoyl-CoA hydratase activity [inference]

3-hydroxyacyl-CoA dehydratase activity

very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity

binding [inference]

protein binding

enzyme binding

Gene Ontology information from NCBI Gene and UniProt.

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026