GlyCosmos Portal

angiopoietin-like 4

Summary

Gene Symbol

Angptl4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

57875

PubChem

57875

Alliance of Genome Resources

MGI:1888999

Annotation

Keyword

Angiogenesis
Coiled coil
Disulfide bond
Extracellular matrix
Glycoprotein
Lipid metabolism
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Z1P8	425O18-1 Angiopoietin-like protein 4 Fasting-induced adipose factor Hepatic fibrinogen/angiopoietin-related protein Secreted protein Bk89

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
positive regulation of lipid metabolic process	NAS	12401877
negative regulation of apoptotic process	IDA ISO	10698685
endothelial cell apoptotic process	IDA	10698685
cellular response to starvation	NAS	10862772
angiogenesis	IEA

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

organic substance metabolic process [inference]

lipid metabolic process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

epithelial cell apoptotic process [inference]

endothelial cell apoptotic process

protein unfolding

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

response to stimulus [inference]

response to stress [inference]

response to hypoxia

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of lipid metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of lipid metabolic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of epithelial cell apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of endothelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

regulation of lipase activity [inference]

regulation of lipoprotein lipase activity [inference]

negative regulation of lipoprotein lipase activity

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
collagen-containing extracellular matrix	IBA
extracellular region	IDA ISO	10698685
extracellular space	IBA IDA ISO	10698685 10866690

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

Displaying **all 2** entries
GO Term	Evidence Code	PMID
identical protein binding	IEA ISO
enzyme inhibitor activity	IBA IDA	12401877

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

identical protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

angiopoietin-related protein 4

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
lipid metabolic process
triglyceride homeostasis

Displaying **all 4** entries
InterPro
Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Fibrinogen, conserved site
Fibrinogen-like, C-terminal

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1574	alcohol use disorder	Alliance of Genome Resources

Ortholog

Displaying entries **91 - 100** of **103** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Panthera leo	122213284		PANLE21201
Marmota monax	124092350	9995_0:000cba
Sciurus carolinensis	124968498	30640_0:004ae0
Perognathus longimembris pacificus	125348672	214514_0:000e31
Myodes glareolus	125397633	447135_0:005102
Microtus fortis	126494051	100897_0:004ed1
Acomys russatus	127183562	60746_0:004b2b
Phodopus roborovskii	127217790	109678_0:00102e
Apodemus sylvaticus	127670892	10129_0:004d0c
Peromyscus californicus insignis	128115664	564181_0:001da8

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements