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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

pentraxin 3

Summary

Gene Symbol

PTX3

Organism

Homo sapiens (human)

External Links

NCBI Gene

5806

PubChem

5806

Alliance of Genome Resources

HGNC:9692

JoGo

PTX3

TogoVar

PTX3

Annotation

Keyword

3D-structure
Coiled coil
Disulfide bond
Glycoprotein
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P26022	Pentaxin-related protein PTX3 Tumor necrosis factor alpha-induced protein 5 Tumor necrosis factor-inducible gene 14 protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
ovarian cumulus expansion	IEA
response to yeast	IEA
inflammatory response	TAS	1429570
opsonization	IEA
extracellular matrix organization	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

opsonization

immune response [inference]

innate immune response

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

reproductive process [inference]

ovulation cycle process [inference]

ovarian cumulus expansion

growth [inference]

developmental growth [inference]

ovarian cumulus expansion

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

modulation by host of viral process [inference]

negative regulation by host of viral process

negative regulation by host of viral glycoprotein metabolic process

modulation by host of viral molecular function [inference]

modulation by host of viral catalytic activity [inference]

modulation by host of viral exo-alpha-sialidase activity [inference]

negative regulation by host of viral exo-alpha-sialidase activity

modulation by host of viral glycoprotein metabolic process [inference]

negative regulation by host of viral glycoprotein metabolic process

modulation by host of symbiont catalytic activity [inference]

negative regulation by host of symbiont catalytic activity [inference]

negative regulation by host of viral exo-alpha-sialidase activity

response to other organism [inference]

response to fungus [inference]

response to yeast

defense response to other organism [inference]

innate immune response

rhythmic process [inference]

ovulation cycle process [inference]

ovarian cumulus expansion

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to fungus [inference]

response to yeast

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to fungus [inference]

response to yeast

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

negative regulation of viral entry into host cell

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

negative regulation of viral process [inference]

negative regulation by host of viral glycoprotein metabolic process

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell

regulation of viral process [inference]

negative regulation of viral process [inference]

negative regulation by host of viral glycoprotein metabolic process

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

negative regulation of viral entry into host cell

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of exo-alpha-sialidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of exo-alpha-sialidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of exo-alpha-sialidase activity

regulation of exo-alpha-sialidase activity [inference]

negative regulation of exo-alpha-sialidase activity

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
tertiary granule lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

tertiary granule lumen

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
complement component C1q complex binding	IDA	23544079
complement component C1q complex binding	IBA
(1->3)-beta-D-glucan binding	IEA
protein binding	IPI	19050261 19632990 20363749 21490156 22267482 22786770 28533443 29374201 35102342
identical protein binding	IPI	20363749

GO Hierarchy

molecular function

binding [inference]

protein binding

opsonin binding [inference]

complement component C1q complex binding

complement binding [inference]

complement component C1q complex binding

identical protein binding

carbohydrate binding [inference]

polysaccharide binding [inference]

(1->3)-beta-D-glucan binding

protein-containing complex binding [inference]

complement component C1q complex binding

virion binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050073	invasive aspergillosis	Alliance of Genome Resources
DOID:1485	cystic fibrosis	Alliance of Genome Resources

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026