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Guidelines

MIRAGE

SH3 and multiple ankyrin repeat domains 3

Summary

Gene Symbol

Shank3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

58234

PubChem

58234

Alliance of Genome Resources

MGI:1930016

Annotation

Keyword

3D-structure
ANK repeat
Actin-binding
Alternative promoter usage
Alternative splicing
Cell projection
Coiled coil
Cytoplasm
Methylation
Phosphoprotein
Reference proteome
Repeat
SH3 domain
Synapse

Proteins

Displaying 1 entry
UniProt	Protein Name
Q4ACU6	Proline-rich synapse-associated protein 2 SPANK-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 54 in total

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GO Term	Evidence Code	PMID
MAPK cascade	IGI	15569713
embryonic epithelial tube formation	IGI	15569713
synapse assembly	IMP	21423165
learning or memory	IMP	21558424
learning	ISO

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade

cell population proliferation [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

forebrain neuron differentiation [inference]

striatal medium spiny neuron differentiation

GABAergic neuron differentiation [inference]

striatal medium spiny neuron differentiation

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

glutamate receptor clustering [inference]

AMPA glutamate receptor clustering

guanylate kinase-associated protein clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

glutamate receptor clustering [inference]

AMPA glutamate receptor clustering

guanylate kinase-associated protein clustering

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle assembly [inference]

postsynaptic specialization assembly [inference]

postsynaptic density assembly

postsynaptic specialization organization [inference]

postsynaptic density organization [inference]

postsynaptic density assembly

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

postsynaptic specialization assembly [inference]

postsynaptic density assembly

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

organelle assembly [inference]

postsynaptic specialization assembly [inference]

postsynaptic density assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendritic spine morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

dendritic spine morphogenesis

neuron projection organization [inference]

dendritic spine organization [inference]

dendritic spine morphogenesis

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

negative regulation of cell volume

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

synapse organization [inference]

synapse assembly

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

postsynapse organization [inference]

dendritic spine organization [inference]

dendritic spine morphogenesis

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

associative learning

observational learning [inference]

imitative learning [inference]

vocal learning

memory

learned vocalization behavior or vocal learning [inference]

vocal learning

neuromuscular process [inference]

neuromuscular process controlling balance

behavior [inference]

learning or memory

associative learning

observational learning [inference]

imitative learning [inference]

vocal learning

memory

learned vocalization behavior or vocal learning [inference]

vocal learning

locomotory behavior

locomotory exploration behavior

mechanosensory behavior [inference]

auditory behavior [inference]

vocal learning

exploration behavior

locomotory exploration behavior

vocalization behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

brain morphogenesis

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendritic spine morphogenesis

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

epithelial tube formation [inference]

embryonic epithelial tube formation

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

forebrain neuron differentiation [inference]

striatal medium spiny neuron differentiation

GABAergic neuron differentiation [inference]

striatal medium spiny neuron differentiation

locomotion

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis [inference]

negative regulation of cell volume

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to interleukin-17

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

glutamate receptor clustering [inference]

AMPA glutamate receptor clustering

guanylate kinase-associated protein clustering

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

glutamate receptor clustering [inference]

AMPA glutamate receptor clustering

guanylate kinase-associated protein clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

glutamate receptor clustering [inference]

AMPA glutamate receptor clustering

guanylate kinase-associated protein clustering

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of glutamate receptor signaling pathway [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of synaptic transmission [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of long-term synaptic potentiation

positive regulation of long-term synaptic potentiation

regulation of long-term synaptic depression

negative regulation of synaptic transmission [inference]

long-term synaptic depression

positive regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of synaptic transmission [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of synaptic transmission [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of cellular component organization [inference]

positive regulation of synapse structural plasticity

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of dendritic spine development

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of glutamate receptor signaling pathway [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of behavioral fear response

regulation of fear response [inference]

regulation of behavioral fear response

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of dendritic spine morphogenesis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of dendritic spine development

regulation of dendritic spine development [inference]

positive regulation of dendritic spine development

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of glutamate receptor signaling pathway [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of synaptic transmission [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of long-term synaptic potentiation

positive regulation of long-term synaptic potentiation

regulation of long-term synaptic depression

negative regulation of synaptic transmission [inference]

long-term synaptic depression

positive regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of synaptic transmission [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of cellular component organization [inference]

positive regulation of synapse structural plasticity

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendritic spine morphogenesis

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly

regulation of synapse organization [inference]

regulation of synapse structural plasticity [inference]

positive regulation of synapse structural plasticity

regulation of postsynapse organization

regulation of dendritic spine morphogenesis

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly

positive regulation of cellular component organization [inference]

positive regulation of synapse structural plasticity

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of behavior [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of fear response [inference]

regulation of behavioral fear response

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of biological quality [inference]

regulation of membrane potential [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of synaptic plasticity

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity [inference]

positive regulation of long-term neuronal synaptic plasticity

regulation of long-term synaptic potentiation

positive regulation of long-term synaptic potentiation

regulation of long-term synaptic depression

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

negative regulation of cell volume

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
cytoplasm	IEA
plasma membrane	IDA	16606358
postsynaptic density	ISS
postsynaptic density	ISO
postsynaptic density	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

ciliary membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendritic spine

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

postsynaptic specialization [inference]

postsynaptic density

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor binding	ISO
actin binding	IEA
protein binding	IPI	15569713 16606358 26966193 28469556 28671696 28701918 29111324 31600191
zinc ion binding	ISS
zinc ion binding	ISO

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of synapse [inference]

structural constituent of postsynapse [inference]

structural constituent of postsynaptic specialization [inference]

structural constituent of postsynaptic density

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding

glutamate receptor binding [inference]

ionotropic glutamate receptor binding

cytoskeletal protein binding [inference]

actin binding

protein domain specific binding [inference]

SH3 domain binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

signaling receptor complex adaptor activity [inference]

synaptic receptor adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0080354	Phelan-McDermid syndrome	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026