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peroxisomal biogenesis factor 19

Summary

Gene Symbol

PEX19

Organism

Homo sapiens (human)

External Links

NCBI Gene

5824

PubChem

5824

Alliance of Genome Resources

HGNC:9713

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Host-virus interaction
Membrane
Methylation
Peroxisome
Peroxisome biogenesis
Phosphoprotein
Prenylation
Reference proteome
Zellweger syndrome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0S2Z497	Peroxin-19 Peroxisomal farnesylated protein
P40855	33 kDa housekeeping protein Peroxin-19 Peroxisomal farnesylated protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein stabilization	IDA	14709540 16344115
negative regulation of lipid binding	IDA	19715730
establishment of protein localization to peroxisome	IMP	18782765
chaperone-mediated protein folding	IDA	14709540
protein targeting to peroxisome	IDA IMP	10704444 16344115 16763195 19114594

GO Hierarchy

biological process

cellular process [inference]

protein folding [inference]

chaperone-mediated protein folding

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome membrane

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to peroxisome

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

peroxisome organization

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome

organelle fission [inference]

peroxisome fission

cellular component biogenesis [inference]

membrane biogenesis [inference]

peroxisome membrane biogenesis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to peroxisome

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome membrane

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to peroxisome

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome membrane

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome membrane

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to peroxisome

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

biological regulation [inference]

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of binding [inference]

negative regulation of lipid binding

regulation of binding [inference]

negative regulation of binding [inference]

negative regulation of lipid binding

regulation of lipid binding [inference]

negative regulation of lipid binding

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
membrane	IDA	10051604
peroxisome	IDA ISS	19114594
protein-containing complex	IDA	18174172
nucleoplasm	IDA
peroxisomal membrane	HDA IBA IDA	15713480 21525035 9339377

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10704444 10777694 11402059 11590176 11883941 12096124 12488033 14709540 15713480 16189514 16280322 16344115 16763195 18174172 18782765 19114594 19197237 19715730 20531392 21102411 21525035 25416956 25502805 27107012 28514442 29997244 31467278 31515488 32296183 32814053 33961781 35271311 37398436 38225382
protein carrier chaperone	IDA	11402059 14709540
peroxisome membrane class-1 targeting sequence binding	IDA	14709540
peroxisome membrane targeting sequence binding	IBA
ATPase binding	IPI	11453642

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

ATPase binding

amide binding [inference]

peptide binding [inference]

signal sequence binding [inference]

peroxisome targeting sequence binding [inference]

peroxisome membrane targeting sequence binding

peroxisome membrane class-1 targeting sequence binding

molecular carrier activity [inference]

protein carrier chaperone

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

PEX19

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 2** entries
Gene Ontology
peroxisome membrane targeting sequence binding
protein import into peroxisome membrane

Displaying **all 2** entries
InterPro
Pex19 protein
Pex19, C-terminal domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080486	peroxisome biogenesis disorder 12A	Alliance of Genome Resources
DOID:905	Zellweger syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	19298		MGI:1334458	MOUSE30462
Drosophila melanogaster	34630		FB:FBgn0032407
Caenorhabditis elegans	176239		WB:WBGene00004201
Rattus norvegicus	289233		RGD:1306913	RATNO06481
Danio rerio	324778		ZFIN:ZDB-GENE-050417-424
Canis lupus familiaris	478972			CANLF14437
Xenopus laevis	496096		Xenbase:XB-GENE-17343405
Bos taurus	521522			BOVIN25586
Xenopus laevis	733180		Xenbase:XB-GENE-973481
Pan troglodytes	746746	9598_0:000039		PANTR22736