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RAB6A, member RAS oncogene family

Summary

Gene Symbol

RAB6A

Organism

Homo sapiens (human)

External Links

NCBI Gene

5870

PubChem

5870

Alliance of Genome Resources

HGNC:9786

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasmic vesicle
Direct protein sequencing
ER-Golgi transport
GTP-binding
Golgi apparatus
Host-virus interaction
Hydrolase
Membrane
Methylation
Phosphoprotein
Prenylation
Protein transport
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A024R5J5
P20340
Q53ET8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
intracellular protein transport	IBA
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	TAS	12447383
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP	25962623
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA
intra-Golgi vesicle-mediated transport	IBA

GO Hierarchy

biological process

immune system process [inference]

antigen processing and presentation

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein alkylation [inference]

protein methylation [inference]

peptidyl-cysteine methylation

peptidyl-amino acid modification [inference]

peptidyl-cysteine modification [inference]

peptidyl-cysteine methylation

methylation [inference]

macromolecule methylation [inference]

protein methylation [inference]

peptidyl-cysteine methylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein alkylation [inference]

protein methylation [inference]

peptidyl-cysteine methylation

peptidyl-amino acid modification [inference]

peptidyl-cysteine modification [inference]

peptidyl-cysteine methylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein alkylation [inference]

protein methylation [inference]

peptidyl-cysteine methylation

peptidyl-amino acid modification [inference]

peptidyl-cysteine modification [inference]

peptidyl-cysteine methylation

macromolecule modification [inference]

protein modification process [inference]

protein alkylation [inference]

protein methylation [inference]

peptidyl-cysteine methylation

peptidyl-amino acid modification [inference]

peptidyl-cysteine modification [inference]

peptidyl-cysteine methylation

macromolecule methylation [inference]

protein methylation [inference]

peptidyl-cysteine methylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein alkylation [inference]

protein methylation [inference]

peptidyl-cysteine methylation

peptidyl-amino acid modification [inference]

peptidyl-cysteine modification [inference]

peptidyl-cysteine methylation

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

minus-end-directed organelle transport along microtubule

vesicle-mediated transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

Golgi vesicle transport [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

minus-end-directed organelle transport along microtubule

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to Golgi membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

protein localization to Golgi membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein localization to membrane [inference]

protein localization to Golgi membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

protein localization to Golgi membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein localization to membrane [inference]

protein localization to Golgi membrane

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

Golgi vesicle transport [inference]

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

minus-end-directed organelle transport along microtubule

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

microtubule-based transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

minus-end-directed organelle transport along microtubule

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

minus-end-directed organelle transport along microtubule

establishment of organelle localization [inference]

organelle transport along microtubule [inference]

minus-end-directed organelle transport along microtubule

organelle localization [inference]

establishment of organelle localization [inference]

organelle transport along microtubule [inference]

minus-end-directed organelle transport along microtubule

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

minus-end-directed organelle transport along microtubule

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to Golgi membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

protein localization to Golgi membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein localization to membrane [inference]

protein localization to Golgi membrane

Displaying entries **6 - 10** of 19 in total

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GO Term	Evidence Code	PMID
Golgi apparatus	IDA	11121396 15229288 17562788 18243103 19141279 23091056
Golgi apparatus	IBA
trans-Golgi network	IDA	12447383
cytosol	TAS
cytosol	IDA	12447383

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

microtubule organizing center [inference]

ciliary basal body

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane

acrosomal membrane

trans-Golgi network membrane

bounding membrane of organelle [inference]

Golgi membrane

secretory granule membrane

acrosomal membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

endosome to plasma membrane transport vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

endosome to plasma membrane transport vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

endosome to plasma membrane transport vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

endosome to plasma membrane transport vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

endosome to plasma membrane transport vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

endosome to plasma membrane transport vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
GTPase activity	IDA	16332443 18243103
GTPase activity	IBA
protein binding	IPI	12391317 15878329 16189514 16902405 18243103 19141279 20386726 20643351 21378754 22011575 23091056 23664119 23737971 25107275 25416956 25962623 32296183 32814053 33961781
GTP binding	IDA	16332443 18243103 19141279
protein domain specific binding	IPI	12447383

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

myosin binding [inference]

myosin V binding

protein domain specific binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

RAS-related protein

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
GTP binding

Displaying **all 3** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Small GTP-binding protein domain
Small GTPase

Ortholog

Displaying entries **51 - 59** of 59 in total

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Species	Gene ID	Orthologous MAtrix
Pseudonaja textilis	113451777	PSETE25837
Bos indicus x Bos taurus	113905519	BOBOX34910
Vombatus ursinus	114032764	VOMUR14593
Strigops habroptila	115604092	STRHB01353
Corvus moneduloides	116437394	CORMO15292
Chelonoidis abingdonii	116834366	CHEAB07480
Rhinolophus ferrumequinum	117030011	RHIFE29963
Balaenoptera musculus	118899199	BALMU08635
Panthera leo	122199245	PANLE14191

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OrthoDB (Group)

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Acknowledgements