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Rac family small GTPase 3

Summary

Gene Symbol

RAC3

Organism

Homo sapiens (human)

External Links

NCBI Gene

5881

HGNC

9803

PubChem

5881

Alliance of Genome Resources

HGNC:9803

Annotation

Keyword

3D-structure
Cell membrane
Cell projection
Cytoskeleton
Disease variant
GTP-binding
Glycoprotein
Hydrolase
Intellectual disability
Isopeptide bond
Methylation
Prenylation
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P60763	p21-Rac3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
actin filament organization	IBA
establishment or maintenance of cell polarity	IBA
motor neuron axon guidance	IBA
regulation of cell shape	IBA
regulation of neuron maturation	IEA

GO Hierarchy

biological process

metabolic process [inference]

respiratory burst

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

establishment or maintenance of cell polarity

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

intracellular signal transduction

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rac protein signal transduction

actin filament-based process [inference]

actin cytoskeleton organization

postsynaptic actin cytoskeleton organization

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

central nervous system neuron development [inference]

cerebral cortex GABAergic interneuron development

cell motility [inference]

cell migration [inference]

cell chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

postsynaptic actin cytoskeleton organization

cortical cytoskeleton organization

postsynaptic cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

cellular component assembly [inference]

cell projection assembly

cell projection organization [inference]

cell projection assembly

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

motor neuron axon guidance

membrane organization [inference]

membrane invagination [inference]

plasma membrane invagination [inference]

phagocytosis, engulfment [inference]

engulfment of apoptotic cell

supramolecular fiber organization [inference]

actin filament organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

neuromuscular process controlling balance

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

homeostasis of number of cells within a tissue

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

homeostasis of number of cells within a tissue

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

neuron development [inference]

central nervous system neuron development [inference]

cerebral cortex GABAergic interneuron development

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

central nervous system neuron development [inference]

cerebral cortex GABAergic interneuron development

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

homeostasis of number of cells within a tissue

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

homeostasis of number of cells within a tissue

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of leukocyte migration [inference]

regulation of neutrophil migration

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of neutrophil migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of cell adhesion mediated by integrin

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of cell differentiation [inference]

regulation of neuron differentiation [inference]

regulation of neuron maturation

regulation of cell development [inference]

regulation of cell maturation [inference]

regulation of neuron maturation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

intracellular signal transduction

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rac protein signal transduction

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

regulation of substrate adhesion-dependent cell spreading [inference]

positive regulation of substrate adhesion-dependent cell spreading

regulation of cell adhesion mediated by integrin [inference]

positive regulation of cell adhesion mediated by integrin

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of cell adhesion mediated by integrin

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cell differentiation [inference]

regulation of neuron differentiation [inference]

regulation of neuron maturation

regulation of cell development [inference]

regulation of cell maturation [inference]

regulation of neuron maturation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of cell adhesion mediated by integrin

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of neutrophil migration

regulation of biological quality [inference]

regulation of cell shape

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS
cytosol	TAS
cytoskeleton	IBA
plasma membrane	NAS	27048830
plasma membrane	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

filamentous actin

membrane protein complex [inference]

plasma membrane protein complex [inference]

NADPH oxidase complex

catalytic complex [inference]

oxidoreductase complex [inference]

NADPH oxidase complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cell body [inference]

neuronal cell body

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GO Term	Evidence Code	PMID
GTPase activity	IDA	11956649
GTPase activity	IBA
G protein activity	IEA
protein binding	IPI	11956649 21217774 32296183
GTP binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

G protein activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

calcium-dependent protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

molecular function regulator activity [inference]

G protein activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

GTPase

Functional Category

T: Signal transduction mechanisms
U: Intracellular trafficking, secretion, and vesicular transport

Displaying **all 4** entries
Gene Ontology
GTP binding
nucleotide binding
protein kinase binding
small GTPase-mediated signal transduction

Displaying **all 4** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Small GTP-binding protein domain
Small GTPase Rho
Small GTPase

Rhea

RHEA:19669

H₂O + GTP

H⁺ + phosphate + GDP

Enzyme

PMID

Disease

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000028	Cryptorchidism
HP:0000238	Hydrocephalus
HP:0000248	Brachycephaly
HP:0000289	Broad philtrum
HP:0000316	Hypertelorism
HP:0000343	Long philtrum
HP:0000347	Micrognathia
HP:0000431	Wide nasal bridge
HP:0000463	Anteverted nares

Displaying 1 entry
Disease ID	Disease Name
OMIM:618577	neurodevelopmental disorder with structural brain anomalies and dysmorphic facies

PubChem Disease

MedGen Diseases

Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies

OMIM Phenotypes

NEURODEVELOPMENTAL DISORDER WITH STRUCTURAL BRAIN ANOMALIES AND DYSMORPHIC FACIES; NEDBAF

KEGG Diseases

Neurodevelopmental disorder with dysmorphic facies

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	5879	FB:FBgn0014011
Drosophila melanogaster	5880	FB:FBgn0010333
Xenopus laevis	5881	Xenbase:XB-GENE-6254025
Mus musculus	170758		MOUSE05236
Danio rerio	437027		DANRE32190
Rattus norvegicus	688319		RATNO02504
Macaca mulatta	719305		MACMU13672
Pan troglodytes	747131		PANTR15728
Danio rerio	795167		DANRE03757
Monodelphis domestica	100029873		MONDO11001

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

PubChem Disease

International Collaboration

Acknowledgements