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fucosyltransferase 2

Summary

Gene Symbol

Fut2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

58924

KEGG Gene ID

rno:58924

PubChem

58924

Alliance of Genome Resources

RGD:2639

Annotation

Keyword

Alternative splicing
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A6JB65
A0A0G2JSS7
Q10984	Alpha 1,2-fucosyltransferase Alpha 1,2-fucosyltransferase B Alpha 1-2 fucosyltransferase Alpha(1,2)FT 2 Fucosyltransferase 2 GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2 Secretor blood group alpha-2-fucosyltransferase Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2 Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
oligosaccharide biosynthetic process	IEA ISO
regulation of endothelial cell proliferation	ISS
glycolipid metabolic process	IEA ISO ISS
fucosylation	IBA IDA IEA ISO	11341836
protein glycosylation	IBA IEA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation [inference]

fucosylation

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

carbohydrate derivative metabolic process [inference]

liposaccharide metabolic process [inference]

glycolipid metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cell adhesion

regulation of cell population proliferation [inference]

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi cisterna membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
alpha-(1,2)-fucosyltransferase activity	IDA ISO	11341836
fucosyltransferase activity	ISO
galactoside 2-alpha-L-fucosyltransferase activity	IBA IDA IEA ISO	11179967

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

fucosyltransferase activity

alpha-(1,2)-fucosyltransferase activity

galactoside 2-alpha-L-fucosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00718

Name

galactoside 2-L-fucosyltransferase 1/2 [EC:2.4.1.69]

References

Reactions

Displaying entries **1 - 10** of 12 in total

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KEGG Reaction	Enzyme	Acceptor	Product
R06085	2.4.1.69	G98726UE	G98900YM
R06156	2.4.1.69	G00049MO	G00050MO
R06089	2.4.1.69	G98726UE	G28261RX
R06086	2.4.1.69	G98900YM	G87164WU
R06090	2.4.1.69	G28261RX	G87164WU
R06035	2.4.1.69	G84034JH	G66427ZQ
R06170	2.4.1.69	G56390QA	G63238VS
R05968	2.4.1.69	G99053DY	G98465JN
R06024	2.4.1.69	G58896AZ	G13636IT
R06031	2.4.1.69	G64885AH	G58990QD

Rhea

RHEA:50668

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + GDP-β-L-fucose

an α-L-Fuc-(1→2)-β-D-Gal-(1→4)-β-D-GlcNAc derivative + H⁺ + GDP

Enzyme

2.4.1.344

PMID

RHEA:50664

a β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl derivative + GDP-β-L-fucose

an α-L-Fuc-(1→2)-β-D-Gal-(1→3)-β-D-GlcNAc derivative + H⁺ + GDP

Enzyme

2.4.1.69

PMID

RHEA:32175

a β-D-Gal-(1→3)-β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-β-D-Glc-(1↔1ʼ)-Cer(d18:1(4E)) + GDP-β-L-fucose

H⁺ + α-L-fucosyl-(1→2)- β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1ʼ)-N-acylsphing-4-enine + GDP

Enzyme

2.4.1.69

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050731	vitamin B12 deficiency	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP012663
Gene Name: fucosyltransferase 2 (secretor status included)

Ortholog

Displaying entries **1 - 10** of 40 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	172980	WB:WBGene00015019
Callorhinchus milii	103173436		CALMI48106
Callorhinchus milii	103183767		CALMI28296
Callorhinchus milii	103183768		CALMI28295
Callorhinchus milii	103183770		CALMI48106
Xenopus tropicalis	447958	Xenbase:XB-GENE-986117
Xenopus tropicalis	100493351	Xenbase:XB-GENE-5995364
Callithrix jacchus	100896666		CALJA24503
Macaca mulatta	722582		MACMU18062
Gorilla gorilla gorilla	129528633		GORGO15088

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements