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butyrylcholinesterase

Summary

Gene Symbol

BCHE

Organism

Homo sapiens (human)

External Links

NCBI Gene

590

PubChem

590

Alliance of Genome Resources

HGNC:983

Annotation

Keyword

3D-structure
Direct protein sequencing
Disease variant
Disulfide bond
Phosphoprotein
Reference proteome
Secreted
Serine esterase
Sialic acid
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P06276	Acylcholine acylhydrolase Butyrylcholine esterase Choline esterase II Pseudocholinesterase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
peptide hormone processing	TAS
choline metabolic process	IBA
response to alkaloid	IEA
cocaine metabolic process	TAS	8622553
negative regulation of synaptic transmission	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

ammonium ion metabolic process [inference]

choline metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

acetylcholine metabolic process [inference]

acetylcholine catabolic process

alkaloid metabolic process [inference]

tropane alkaloid metabolic process [inference]

cocaine metabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

choline metabolic process

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

hormone metabolic process [inference]

peptide hormone processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

cocaine metabolic process

xenobiotic metabolic process

heterocycle metabolic process [inference]

tropane alkaloid metabolic process [inference]

cocaine metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

acetate ester metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine catabolic process

organic cyclic compound metabolic process [inference]

tropane alkaloid metabolic process [inference]

cocaine metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

acetylcholine metabolic process [inference]

acetylcholine catabolic process

alkaloid metabolic process [inference]

tropane alkaloid metabolic process [inference]

cocaine metabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

choline metabolic process

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

cocaine metabolic process

xenobiotic metabolic process

heterocycle metabolic process [inference]

tropane alkaloid metabolic process [inference]

cocaine metabolic process

cellular developmental process [inference]

cell differentiation [inference]

neuroblast differentiation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

learning or memory [inference]

learning

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

neuroblast differentiation

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to folic acid

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to folic acid

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organonitrogen compound [inference]

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to folic acid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to oxygen-containing compound [inference]

response to folic acid

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

negative regulation of synaptic transmission

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of synaptic transmission

regulation of cellular process [inference]

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

negative regulation of synaptic transmission

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of synaptic transmission

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular region	NAS	14718574
extracellular region	TAS
extracellular space	IBA
nuclear envelope lumen	IEA
endoplasmic reticulum lumen	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle envelope lumen [inference]

nuclear envelope lumen

blood microparticle

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
amyloid-beta binding	NAS	11569538
catalytic activity	NAS	11569538
acetylcholinesterase activity	ISS
acetylcholinesterase activity	IBA
cholinesterase activity	IDA	19452557

GO Hierarchy

molecular function

catalytic activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds

carboxylic ester hydrolase activity [inference]

cholinesterase activity

acetylcholinesterase activity

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

ion binding [inference]

cation binding [inference]

choline binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Carboxylesterase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
hydrolase activity

Displaying **all 4** entries
InterPro
Alpha/Beta hydrolase fold
Carboxylesterase type B, active site
Carboxylesterase type B, conserved site
Carboxylesterase, type B

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:4247	coronary restenosis	Alliance of Genome Resources
DOID:655	inherited metabolic disorder	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	181706	Xenbase:XB-GENE-980117
Pan troglodytes	460830		PANTR32582
Canis lupus familiaris	488143		CANLF13616
Felis catus	493960		FELCA23175
Bos taurus	534616		BOVIN15055
Macaca mulatta	700484		MACMU29576
Ornithorhynchus anatinus	100074368		ORNAN11588
Ciona intestinalis	100169895		CIOIN03667
Pongo abelii	100174585		PONAB25541
Taeniopygia guttata	100229708		TAEGU30307