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butyrylcholinesterase

Summary

Gene Symbol

BCHE

Organism

Homo sapiens (human)

External Links

NCBI Gene

590

PubChem

590

Alliance of Genome Resources

HGNC:983

Annotation

Keyword

3D-structure
Direct protein sequencing
Disease variant
Disulfide bond
Phosphoprotein
Reference proteome
Secreted
Serine esterase
Sialic acid
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P06276	Acylcholine acylhydrolase Butyrylcholine esterase Choline esterase II Pseudocholinesterase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
acetylcholine catabolic process	IBA
xenobiotic metabolic process	TAS
learning	IEA
negative regulation of cell population proliferation	IEA
neuroblast differentiation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

ammonium ion metabolic process [inference]

choline metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

acetylcholine metabolic process [inference]

acetylcholine catabolic process

alkaloid metabolic process [inference]

tropane alkaloid metabolic process [inference]

cocaine metabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

choline metabolic process

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

hormone metabolic process [inference]

peptide hormone processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

cocaine metabolic process

xenobiotic metabolic process

heterocycle metabolic process [inference]

tropane alkaloid metabolic process [inference]

cocaine metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

acetate ester metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine catabolic process

organic cyclic compound metabolic process [inference]

tropane alkaloid metabolic process [inference]

cocaine metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

acetylcholine metabolic process [inference]

acetylcholine catabolic process

alkaloid metabolic process [inference]

tropane alkaloid metabolic process [inference]

cocaine metabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

choline metabolic process

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

cocaine metabolic process

xenobiotic metabolic process

heterocycle metabolic process [inference]

tropane alkaloid metabolic process [inference]

cocaine metabolic process

cellular developmental process [inference]

cell differentiation [inference]

neuroblast differentiation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

learning or memory [inference]

learning

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

neuroblast differentiation

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to folic acid

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to folic acid

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organonitrogen compound [inference]

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to folic acid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to oxygen-containing compound [inference]

response to folic acid

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

negative regulation of synaptic transmission

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of synaptic transmission

regulation of cellular process [inference]

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

negative regulation of synaptic transmission

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of synaptic transmission

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
plasma membrane	IBA
blood microparticle	HDA	22516433

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle envelope lumen [inference]

nuclear envelope lumen

blood microparticle

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
amyloid-beta binding	NAS	11569538
catalytic activity	NAS	11569538
acetylcholinesterase activity	ISS
acetylcholinesterase activity	IBA
cholinesterase activity	IDA	19452557

GO Hierarchy

molecular function

catalytic activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds

carboxylic ester hydrolase activity [inference]

cholinesterase activity

acetylcholinesterase activity

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

ion binding [inference]

cation binding [inference]

choline binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Carboxylesterase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
hydrolase activity

Displaying **all 4** entries
InterPro
Alpha/Beta hydrolase fold
Carboxylesterase type B, active site
Carboxylesterase type B, conserved site
Carboxylesterase, type B

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:4247	coronary restenosis	Alliance of Genome Resources
DOID:655	inherited metabolic disorder	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	43	FB:FBgn0000024
Xenopus tropicalis	590	Xenbase:XB-GENE-980117
Drosophila melanogaster	11423	FB:FBgn0000024
Mus musculus	12038	Xenbase:XB-GENE-980117	MOUSE36533
Xenopus tropicalis	41625	Xenbase:XB-GENE-980117
Rattus norvegicus	65036		RATNO24582
Drosophila melanogaster	83817	FB:FBgn0000024
Drosophila melanogaster	114549	FB:FBgn0000024
Drosophila melanogaster	171905	FB:FBgn0000024
Caenorhabditis elegans	175076	WB:WBGene00000037