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Rap1 GTPase-GDP dissociation stimulator 1

Summary

Gene Symbol

RAP1GDS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5910

PubChem

5910

Alliance of Genome Resources

HGNC:9859

JoGo

RAP1GDS1

TogoVar

RAP1GDS1

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Chromosomal rearrangement
Cytoplasm
Endoplasmic reticulum
Guanine-nucleotide releasing factor
Intellectual disability
Mitochondrion
Nucleus
Proteomics identification
Reference proteome
Repeat

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q6U7G8
B3KNU0
P52306	Exchange factor smgGDS SMG GDS protein SMG P21 stimulatory GDP/GTP exchange protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cardiac muscle hypertrophy	IEA
regulation of mitochondrion organization	IMP	27716788
vascular associated smooth muscle contraction	IEA
myosin filament assembly	IEA
negative regulation of endoplasmic reticulum calcium ion concentration	IMP	24349085

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

CAAX-box protein maturation

primary metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

CAAX-box protein maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

CAAX-box protein maturation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

CAAX-box protein maturation

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

angiotensin-activated signaling pathway [inference]

angiotensin-activated signaling pathway involved in heart process

G protein-coupled receptor signaling pathway involved in heart process [inference]

angiotensin-activated signaling pathway involved in heart process

actin filament-based process [inference]

actin cytoskeleton organization [inference]

myosin filament organization [inference]

myosin filament assembly

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

myosin filament organization [inference]

myosin filament assembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

myosin filament assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

myosin filament assembly

supramolecular fiber organization [inference]

myosin filament organization [inference]

myosin filament assembly

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction [inference]

vascular associated smooth muscle contraction

muscle hypertrophy [inference]

striated muscle hypertrophy [inference]

cardiac muscle hypertrophy

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

vascular associated smooth muscle contraction

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

negative regulation of endoplasmic reticulum calcium ion concentration

mitochondrial calcium ion homeostasis [inference]

positive regulation of mitochondrial calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

negative regulation of endoplasmic reticulum calcium ion concentration

mitochondrial calcium ion homeostasis [inference]

positive regulation of mitochondrial calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

negative regulation of endoplasmic reticulum calcium ion concentration

mitochondrial calcium ion homeostasis [inference]

positive regulation of mitochondrial calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

negative regulation of endoplasmic reticulum calcium ion concentration

mitochondrial calcium ion homeostasis [inference]

positive regulation of mitochondrial calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

negative regulation of endoplasmic reticulum calcium ion concentration

mitochondrial calcium ion homeostasis [inference]

positive regulation of mitochondrial calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

negative regulation of endoplasmic reticulum calcium ion concentration

mitochondrial calcium ion homeostasis [inference]

positive regulation of mitochondrial calcium ion concentration

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK5 cascade

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

regulation of matrix metallopeptidase secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of matrix metallopeptidase secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of matrix metallopeptidase secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK5 cascade

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

angiotensin-activated signaling pathway [inference]

angiotensin-activated signaling pathway involved in heart process

G protein-coupled receptor signaling pathway involved in heart process [inference]

angiotensin-activated signaling pathway involved in heart process

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK5 cascade

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of mitochondrion organization

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of matrix metallopeptidase secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

regulation of matrix metallopeptidase secretion

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

vascular associated smooth muscle contraction

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	12551911
mitochondrion	IDA	24349085
endoplasmic reticulum	IDA	24349085
cytosol	IDA	24349085
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	IDA	21242305 28630045 30190425
protein binding	IPI	20936779 24415755 25416956 27716788 28630045 30190425 31406347 31980649 32296183 32353859 32814053 32838362 33060197 33961781 34159380 35271311 36217030