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latent transforming growth factor beta binding protein 1

Summary

Gene Symbol

Ltbp1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

59107

PubChem

59107

Alliance of Genome Resources

RGD:68379

Annotation

Keyword

Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein
Growth factor binding
Hydroxylation
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q00918	Transforming growth factor beta-1-binding protein 1 Transforming growth factor beta-1-masking protein large subunit
A0A8I5Y739	Transforming growth factor beta-1-binding protein 1
A6H9X2	Transforming growth factor beta-1-binding protein 1
A0A8I6AA33	Transforming growth factor beta-1-binding protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
ventricular septum development	ISO
positive regulation of collagen biosynthetic process	IMP	9607192
sequestering of TGFbeta in extracellular matrix	ISS
sequestering of TGFbeta in extracellular matrix	ISO
sequestering of TGFbeta in extracellular matrix	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to extracellular region

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to organic cyclic compound [inference]

cellular response to vitamin D

cellular response to oxygen-containing compound [inference]

cellular response to vitamin D

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

developmental process [inference]

anatomical structure development [inference]

blood vessel development [inference]

artery development [inference]

aorta development

coronary vasculature development

cardiac septum development [inference]

ventricular septum development

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

response to vitamin [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to mechanical stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

response to parathyroid hormone [inference]

cellular response to parathyroid hormone stimulus

response to growth factor [inference]

response to platelet-derived growth factor [inference]

cellular response to platelet-derived growth factor stimulus

cellular response to growth factor stimulus [inference]

cellular response to platelet-derived growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to growth factor stimulus [inference]

cellular response to platelet-derived growth factor stimulus

response to chemical [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

response to vitamin [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to vitamin [inference]

cellular response to vitamin D

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

response to parathyroid hormone [inference]

cellular response to parathyroid hormone stimulus

response to organic cyclic compound [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to organic cyclic compound [inference]

cellular response to vitamin D

response to lipid [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to organic cyclic compound [inference]

cellular response to vitamin D

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to organic cyclic compound [inference]

cellular response to vitamin D

cellular response to oxygen-containing compound [inference]

cellular response to vitamin D

response to oxygen-containing compound [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to oxygen-containing compound [inference]

cellular response to vitamin D

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to organic cyclic compound [inference]

cellular response to vitamin D

cellular response to oxygen-containing compound [inference]

cellular response to vitamin D

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to extracellular region

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region

establishment of localization [inference]

establishment of protein localization [inference]

establishment of protein localization to extracellular region

maintenance of location [inference]

maintenance of protein location [inference]

maintenance of protein location in extracellular region [inference]

sequestering of TGFbeta in extracellular matrix

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to extracellular region

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of collagen biosynthetic process

regulation of collagen biosynthetic process [inference]

positive regulation of collagen biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of collagen biosynthetic process

positive regulation of collagen metabolic process [inference]

positive regulation of collagen biosynthetic process

regulation of collagen metabolic process [inference]

positive regulation of collagen metabolic process [inference]

positive regulation of collagen biosynthetic process

regulation of collagen biosynthetic process [inference]

positive regulation of collagen biosynthetic process

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of TGFbeta in extracellular matrix

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of TGFbeta in extracellular matrix

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of collagen biosynthetic process

positive regulation of collagen metabolic process [inference]

positive regulation of collagen biosynthetic process

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of TGFbeta in extracellular matrix

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of TGFbeta in extracellular matrix

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of TGFbeta in extracellular matrix

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of TGFbeta in extracellular matrix

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of TGFbeta in extracellular matrix

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
microfibril	ISS
microfibril	ISO
microfibril	IEA
extracellular region	IEA
dendrite	IDA	11720783

GO Hierarchy

cellular component

protein-containing complex

large latent transforming growth factor-beta complex

cellular anatomical entity [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

microfibril

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
calcium ion binding	IEA
transforming growth factor beta binding	ISO
transforming growth factor beta binding	IEA
microfibril binding	ISO
microfibril binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

growth factor binding [inference]

transforming growth factor beta binding

cytokine binding [inference]

transforming growth factor beta binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

microfibril binding

molecular adaptor activity

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

receptor ligand inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
dendrite	PMID:11720783
neuronal cell body	PMID:11720783
collagen-containing extracellular matrix	PMID:9766531
large latent transforming growth factor-beta complex	PMID:11907708
perinuclear region of cytoplasm	PMID:9828223

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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