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Guidelines

MIRAGE

atypical chemokine receptor 2

Summary

Gene Symbol

Ackr2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

59289

PubChem

59289

Alliance of Genome Resources

MGI:1891697

Annotation

Keyword

Cell membrane
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Inflammatory response
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O08707	C-C chemokine receptor D6 Chemokine-binding protein 2 Chemokine-binding protein D6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
chemotaxis	IEA
inflammatory response	IEA
immune response	IBA
signal transduction	IDA	9139699
positive regulation of cytosolic calcium ion concentration	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

vesicle-mediated transport

cell motility [inference]

cell migration [inference]

cell chemotaxis

locomotion [inference]

taxis [inference]

cell chemotaxis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

immune response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
nucleoplasm	ISO
nucleoplasm	IEA
early endosome	IEA
cytosol	ISO
cytosol	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

nuclear membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

side of membrane [inference]

external side of plasma membrane

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
chemokine receptor activity	ISO
scavenger receptor activity	ISS
scavenger receptor activity	ISO
protein binding	IPI	9139699
C-C chemokine receptor activity	IDA	9139699

GO Hierarchy

molecular function

binding [inference]

protein binding

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

cargo receptor activity [inference]

scavenger receptor activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

G protein-coupled receptor activity [inference]

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

C-X-C chemokine receptor type a

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
C-C chemokine binding
C-C chemokine receptor activity
calcium-mediated signaling
cell chemotaxis
chemokine receptor activity
chemokine-mediated signaling pathway
chemotaxis
immune response
positive regulation of cytosolic calcium ion concentration

Displaying **all 3** entries
InterPro
Chemokine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	643	WB:WBGene00011578
Caenorhabditis elegans	1230	WB:WBGene00011578
Caenorhabditis elegans	1232	WB:WBGene00011578
Caenorhabditis elegans	1233	WB:WBGene00011578
Caenorhabditis elegans	1234	WB:WBGene00011578
Caenorhabditis elegans	1235	WB:WBGene00011578
Caenorhabditis elegans	1236	WB:WBGene00011578
Homo sapiens	1238	HGNC:1565	HUMAN69474
Caenorhabditis elegans	2833	WB:WBGene00011578
Caenorhabditis elegans	3577	WB:WBGene00011578

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025