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replication factor C subunit 4

Summary

Gene Symbol

RFC4

Organism

Homo sapiens (human)

External Links

NCBI Gene

5984

PubChem

5984

Alliance of Genome Resources

HGNC:9972

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
DNA replication
Deafness
Direct protein sequencing
Nucleus
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P35249	Activator 1 37 kDa subunit Activator 1 subunit 4 Replication factor C 37 kDa subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
DNA-templated DNA replication	IDA	9488738
DNA-templated DNA replication	IBA
DNA strand elongation involved in DNA replication	TAS	7774928
DNA repair	IBA
DNA duplex unwinding

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

DNA conformation change [inference]

DNA geometric change [inference]

DNA duplex unwinding

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of transferase activity [inference]

positive regulation of transferase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA
DNA replication factor C complex	IDA	9488738
DNA replication factor C complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

DNA replication factor C complex

nuclear protein-containing complex [inference]

Ctf18 RFC-like complex

catalytic complex [inference]

Elg1 RFC-like complex

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

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GO Term	Evidence Code	PMID
DNA binding	IEA
DNA clamp loader activity	IDA	12930902
DNA clamp loader activity	IBA
protein binding	IPI	15655353 16189514 21516116 23277426 25416956 28514442 29892012 30021884 31515488 32296183 33961781 9488738
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity [inference]

DNA helicase activity [inference]

single-stranded DNA helicase activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity [inference]

single-stranded DNA helicase activity

DNA clamp loader activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity [inference]

DNA helicase activity [inference]

single-stranded DNA helicase activity

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity [inference]

single-stranded DNA helicase activity

DNA clamp loader activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

replication factor

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
DNA repair
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ATPase, AAA-type, core
DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
P-loop containing nucleoside triphosphate hydrolase
Replication factor C, C-terminal
Replication factor C, lid domain

Ortholog

Displaying entries **1 - 10** of 82 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5984	Xenbase:XB-GENE-955724
Mus musculus	106344	Xenbase:XB-GENE-955724	MOUSE19123
Rattus norvegicus	288003		RATNO03664
Canis lupus familiaris	478667		CANLF13563
Bos taurus	504637		BOVIN14817
Equus caballus	100068189		HORSE14119
Ornithorhynchus anatinus	100082799		ORNAN11853
Ciona intestinalis	100181635		CIOIN10538
Taeniopygia guttata	100227869		TAEGU29873
Oryctolagus cuniculus	100342140		RABIT04612

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements