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regulator of G protein signaling 1

Summary

Gene Symbol

RGS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5996

PubChem

5996

Alliance of Genome Resources

HGNC:9991

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cytoplasm
GTPase activation
Reference proteome
Signal transduction inhibitor

Proteins

Displaying 1 entry
UniProt	Protein Name
Q08116	B-cell activation protein BL34 Early response protein 1R20

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
immune response	TAS	8241276
signal transduction	IDA	10480894
G protein-coupled receptor signaling pathway	TAS
G protein-coupled receptor signaling pathway	IDA	10480894
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS	10480894

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

leukotriene signaling pathway

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

leukotriene signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol	IDA	10480894
plasma membrane	TAS
cytoplasmic side of plasma membrane	IDA	10480894

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
G-protein alpha-subunit binding	IPI	18434541
GTPase activity	TAS
GTPase activator activity	IDA	10480894 18434541
calmodulin binding	TAS	10747990

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

protein binding [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

regulator of G signaling

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
RGS domain superfamily
RGS domain
RGS, subdomain 2

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4507	Xenbase:XB-GENE-968765
Xenopus tropicalis	5996	Xenbase:XB-GENE-968765
Xenopus tropicalis	36955	Xenbase:XB-GENE-968765
Mus musculus	50778		MOUSE30574
Rattus norvegicus	54289		RATNO06719
Xenopus tropicalis	66902	Xenbase:XB-GENE-968765
Caenorhabditis elegans	85397	WB:WBGene00004353
Xenopus tropicalis	318597	Xenbase:XB-GENE-968765
Xenopus tropicalis	393526	Xenbase:XB-GENE-968765
Sus scrofa	397336		PIGXX00009

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OrthoDB (Group)

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Acknowledgements