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rhodopsin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

6010

PubChem

6010

Alliance of Genome Resources

HGNC:10012

Annotation

Keyword

3D-structure
Acetylation
Cell projection
Congenital stationary night blindness
Disease variant
Disulfide bond
G-protein coupled receptor
Glycoprotein
Metal-binding
Palmitate
Phosphoprotein
Reference proteome
Retinal protein
Retinitis pigmentosa
Transmembrane helix
Vision
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P08100	Opsin-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
microtubule cytoskeleton organization	IEA
G protein-coupled receptor signaling pathway	IMP	2218504
G protein-coupled receptor signaling pathway	IBA
visual perception	IEA
phototransduction	IBA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

signal transduction [inference]

G protein-coupled receptor signaling pathway

rhodopsin mediated signaling pathway

phototransduction

light absorption [inference]

absorption of visible light

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

glutamatergic neuron differentiation [inference]

retinal bipolar neuron differentiation [inference]

rod bipolar cell differentiation

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

rhodopsin mediated signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

podosome assembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

podosome assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

podosome assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

podosome assembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

photoreceptor cell maintenance

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

glutamatergic neuron differentiation [inference]

retinal bipolar neuron differentiation [inference]

rod bipolar cell differentiation

locomotion [inference]

taxis [inference]

thermotaxis

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of visible light [inference]

phototransduction, visible light

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

thermotaxis

response to radiation [inference]

response to light stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of visible light [inference]

phototransduction, visible light

response to light intensity

cellular response to light stimulus

rhodopsin mediated signaling pathway

cellular response to radiation [inference]

cellular response to light stimulus

rhodopsin mediated signaling pathway

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of visible light [inference]

phototransduction, visible light

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

rhodopsin mediated signaling pathway

detection of stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of visible light [inference]

phototransduction, visible light

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of visible light [inference]

phototransduction, visible light

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

detection of stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

rhodopsin mediated signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

rhodopsin mediated signaling pathway

phototransduction

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
photoreceptor outer segment	IDA	11767049 23704327
photoreceptor outer segment	IBA
photoreceptor inner segment	IDA	11767049
Golgi apparatus	IDA	11767049

GO Hierarchy

cellular component

cellular anatomical entity [inference]

photoreceptor outer segment

rod photoreceptor outer segment

photoreceptor inner segment

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

Golgi-associated vesicle membrane

photoreceptor disc membrane

bounding membrane of organelle [inference]

ciliary membrane

photoreceptor outer segment membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

photoreceptor outer segment membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

sperm midpiece

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GO Term	Evidence Code	PMID
G protein-coupled receptor activity	TAS	8107847
11-cis retinal binding	ISS
protein binding	IPI	12754272 17693260 19934218 32296183
G protein-coupled photoreceptor activity	ISS
G protein-coupled photoreceptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

isoprenoid binding [inference]

retinoid binding [inference]

retinal binding [inference]

11-cis retinal binding

small molecule binding [inference]

vitamin binding [inference]

retinal binding [inference]

11-cis retinal binding

ion binding [inference]

cation binding [inference]

metal ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled photoreceptor activity

photoreceptor activity [inference]

G protein-coupled photoreceptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Green-sensitive opsin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
cellular response to light stimulus
metal ion binding
photoreceptor activity
phototransduction
visual perception

Displaying **all 6** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Opsin
Rhodopsin, N-terminal
Rhodopsin
Visual pigments (opsins) retinal binding site

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0110372	retinitis pigmentosa 4	Alliance of Genome Resources
DOID:0110862	congenital stationary night blindness autosomal dominant 1	Alliance of Genome Resources
DOID:10584	retinitis pigmentosa	Alliance of Genome Resources
DOID:11105	fundus albipunctatus	Alliance of Genome Resources
DOID:8499	night blindness	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6010	Xenbase:XB-GENE-966887
Rattus norvegicus	24717	Xenbase:XB-GENE-966887	RATNO29856
Xenopus tropicalis	30295	Xenbase:XB-GENE-966887
Xenopus tropicalis	30459	Xenbase:XB-GENE-966887
Mus musculus	212541	Xenbase:XB-GENE-966887	MOUSE50392
Xenopus tropicalis	380209	Xenbase:XB-GENE-966887
Sus scrofa	397437		PIGXX04624
Pan troglodytes	460685		PANTR32158
Felis catus	493762		FELCA05036
Canis lupus familiaris	493763		CANLF07257