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G protein-coupled receptor kinase 1

Summary

Gene Symbol

GRK1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6011

PubChem

6011

Alliance of Genome Resources

HGNC:10013

Annotation

Keyword

3D-structure
ATP-binding
Cell projection
Congenital stationary night blindness
Disease variant
Membrane
Methylation
Phosphoprotein
Prenylation
Reference proteome
Serine/threonine-protein kinase
Vision

Proteins

Displaying 1 entry
UniProt	Protein Name
Q15835	G protein-coupled receptor kinase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
visual perception	IEA
regulation of G protein-coupled receptor signaling pathway	TAS	1656454
regulation of signal transduction	IBA
rhodopsin mediated signaling pathway	TAS	1656454 9147475
regulation of rhodopsin mediated signaling pathway	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

protein autophosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

rhodopsin mediated signaling pathway

phototransduction [inference]

rhodopsin mediated signaling pathway

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

protein autophosphorylation

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

rhodopsin mediated signaling pathway

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

rhodopsin mediated signaling pathway

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

rhodopsin mediated signaling pathway

cellular response to light stimulus [inference]

rhodopsin mediated signaling pathway

cellular response to radiation [inference]

cellular response to light stimulus [inference]

rhodopsin mediated signaling pathway

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

rhodopsin mediated signaling pathway

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

rhodopsin mediated signaling pathway

detection of stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

rhodopsin mediated signaling pathway

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

rhodopsin mediated signaling pathway

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

rhodopsin mediated signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction

regulation of G protein-coupled receptor signaling pathway

regulation of rhodopsin mediated signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction

regulation of G protein-coupled receptor signaling pathway

regulation of rhodopsin mediated signaling pathway

regulation of response to external stimulus [inference]

regulation of rhodopsin mediated signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

rhodopsin mediated signaling pathway

phototransduction [inference]

rhodopsin mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction

regulation of G protein-coupled receptor signaling pathway

regulation of rhodopsin mediated signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytoplasm	IBA
photoreceptor disc membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

photoreceptor disc membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein kinase activity	TAS	1656454 9147475
ATP binding	IEA
rhodopsin kinase activity	TAS
rhodopsin kinase activity	IDA	15946941
rhodopsin kinase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity [inference]

G protein-coupled receptor kinase activity [inference]

rhodopsin kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity [inference]

G protein-coupled receptor kinase activity [inference]

rhodopsin kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity [inference]

G protein-coupled receptor kinase activity [inference]

rhodopsin kinase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

g protein-coupled receptor kinase

Functional Category

C: Energy production and conversion
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
kinase activity
nucleotide binding
phosphorylation
transferase activity

Displaying **all 9** entries
InterPro
AGC-kinase, C-terminal
GPCR kinase
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
RGS domain superfamily
RGS domain
RGS, subdomain 2
Serine/threonine-protein kinase, active site

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110713	Oguchi disease-2	Alliance of Genome Resources
DOID:8499	night blindness	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6011	Xenbase:XB-GENE-1012638
Mus musculus	24013		MOUSE58016
Rattus norvegicus	81760		RATNO10780
Drosophila melanogaster	131890	FB:FBgn0261988
Bos taurus	281457		BOVIN04180
Pan troglodytes	467338		PANTR08151
Canis lupus familiaris	485557		CANLF08880
Danio rerio	564152		DANRE16583
Monodelphis domestica	100016174		MONDO31694
Equus caballus	100069151		HORSE12430