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Guidelines

MIRAGE

ribonuclease A family member 1, pancreatic

Summary

Gene Symbol

RNASE1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6035

PubChem

6035

Alliance of Genome Resources

HGNC:10044

Annotation

Keyword

3D-structure
Direct protein sequencing
Disulfide bond
Endonuclease
Glycoprotein
Lyase
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P07998	HP-RNase RIB-1 RNase UpI-1 Ribonuclease 1 Ribonuclease A
W0UV93

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
defense response to Gram-positive bacterium	IBA
defense response to virus	IDA	9826755

GO Hierarchy

biological process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to symbiont [inference]

defense response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to symbiont [inference]

defense response to virus

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to symbiont [inference]

defense response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to symbiont [inference]

defense response to virus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleic acid binding	IEA
endonuclease activity
ribonuclease A activity	IEA
RNA nuclease activity	IDA	9826755
RNA nuclease activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 3'-phosphomonoesters [inference]

ribonuclease A activity

endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [inference]

RNA endonuclease activity, producing 3'-phosphomonoesters [inference]

ribonuclease A activity

RNA nuclease activity

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 3'-phosphomonoesters [inference]

ribonuclease A activity

lyase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA nuclease activity

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 3'-phosphomonoesters [inference]

ribonuclease A activity

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ribonuclease

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
RNA nuclease activity
defense response to Gram-positive bacterium
endonuclease activity
hydrolase activity
nuclease activity

Displaying **all 4** entries
InterPro
Pancreatic ribonuclease
Ribonuclease A, active site
Ribonuclease A-domain
Ribonuclease A-like domain superfamily

Ortholog

Displaying entries **11 - 20** of 56 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	364304		RATNO09413
Pan troglodytes	465207		PANTR08215
Canis lupus familiaris	475395		CANLF04152
Macaca mulatta	704676		MACMU40543
Equus caballus	100058995		HORSE14993
Pongo abelii	100173814		PONAB07361
Sus scrofa	100312980		PIGXX32515
Oryctolagus cuniculus	100351089		RABIT06288
Callithrix jacchus	100389327		CALJA02149
Ailuropoda melanoleuca	100467619		AILME03957

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025