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ribonuclease A family member 2

Summary

Gene Symbol

RNASE2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6036

KEGG Gene ID

PubChem

6036

Alliance of Genome Resources

HGNC:10045

Annotation

Keyword

3D-structure
Chemotaxis
Direct protein sequencing
Disulfide bond
Endonuclease
Glycoprotein
Lyase
Lysosome
Neurotoxin
Nitration
Proteomics identification
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P10153	Eosinophil-derived neurotoxin RNase UpI-2 Ribonuclease 2 Ribonuclease US
W0UV60	Eosinophil-derived neurotoxin RNase UpI-2 Ribonuclease 2 Ribonuclease US

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
innate immune response in mucosa	IBA
RNA catabolic process	TAS
chemotaxis	IDA
chemotaxis	IBA
induction of bacterial agglutination	IMP

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

organ or tissue specific immune response [inference]

mucosal immune response [inference]

innate immune response in mucosa

humoral immune response [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

innate immune response [inference]

innate immune response in mucosa

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

nucleic acid catabolic process [inference]

RNA catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

nucleic acid catabolic process [inference]

RNA catabolic process

locomotion [inference]

taxis [inference]

chemotaxis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

innate immune response [inference]

innate immune response in mucosa

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

innate immune response [inference]

innate immune response in mucosa

immune response [inference]

organ or tissue specific immune response [inference]

mucosal immune response [inference]

innate immune response in mucosa

humoral immune response [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

innate immune response [inference]

innate immune response in mucosa

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

innate immune response [inference]

innate immune response in mucosa

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

innate immune response [inference]

innate immune response in mucosa

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	IBA
obsolete extracellular space
lysosome	IEA
azurophil granule lumen	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
RNA nuclease activity	IEA
protein binding	IPI
hydrolase activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

lyase activity [inference]

phosphorus-oxygen lyase activity [inference]

ribonuclease A activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

endonuclease activity [inference]

RNA endonuclease activity [inference]

ribonuclease A activity

RNA nuclease activity

RNA endonuclease activity [inference]

ribonuclease A activity

catalytic activity, acting on RNA [inference]

RNA nuclease activity

RNA endonuclease activity [inference]

ribonuclease A activity

binding [inference]

lipid binding [inference]

lipopolysaccharide binding

carbohydrate derivative binding [inference]

lipopolysaccharide binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	54159	MGI:1858598
Mus musculus	13586	MGI:108021
Mus musculus	53877	MGI:1858238
Mus musculus	53876	MGI:1858237
Mus musculus	13587	MGI:108020

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

GlyCosmos Portal v4.5.0

Last updated: April 6, 2026

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