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MIRAGE
3-hydroxyisobutyryl-CoA hydrolase

Summary
Gene Symbol
  • HIBCH
Organism
Canis lupus familiaris (dog)
NCBI Gene
607040
KEGG Gene ID
cfa:607040
PubChem
607040
Annotation
Keyword
  • Branched-chain amino acid catabolism
  • Hydrolase
  • Mitochondrion
  • Reference proteome
Proteins
Displaying all 2 entries
UniProt Protein Name
A0A8I3S4X3
  • 3-hydroxyisobutyryl-coenzyme A hydrolase
A0A8C0RLB1
  • 3-hydroxyisobutyryl-coenzyme A hydrolase
Annotation information from UniProt.
Gene Ontology (GO)
Displaying 1 entry
GO Term Evidence Code PMID
valine catabolic process
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
3-hydroxyisobutyryl-coa hydrolase
Functional Category
  • G: Carbohydrate transport and metabolism
  • I: Lipid transport and metabolism
  • T: Signal transduction mechanisms
Displaying all 3 entries
Gene Ontology
3-hydroxyisobutyryl-CoA hydrolase activity
hydrolase activity
valine catabolic process
Displaying all 3 entries
InterPro
ClpP/crotonase-like domain superfamily
Enoyl-CoA hydratase/isomerase domain
Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type
KEGG BRITE Database
Orthology
K05605
Name
3-hydroxyisobutyryl-CoA hydrolase [EC:3.1.2.4]
References
Rhea

RHEA:20888

H2O + 3-hydroxy-2-methylpropanoyl-CoA
3-hydroxy-2-methylpropanoate + H+ + CoA
Enzyme
PMID
Ortholog
Displaying entries 1 - 10 of 70 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
26275 HUMAN66026
227095 MOUSE27952
301384 RATNO42358
459828 PANTR29374
535883 BOVIN23888
713951 MACMU05850
798364 DANRE45273
100028760 MONDO22247
100069399 HORSE13484
100084964 ORNAN25460
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025