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replication protein A1

Summary

Gene Symbol

RPA1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6117

PubChem

6117

Alliance of Genome Resources

HGNC:10289

Annotation

Keyword

3D-structure
ADP-ribosylation
Acetylation
DNA recombination
DNA repair
DNA replication
DNA-binding
Direct protein sequencing
Disease variant
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
P27694	Replication factor A protein 1 Single-stranded DNA-binding protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
telomere maintenance	NAS	17959650
telomere maintenance	IC	16973897 24747047 26041456
telomere maintenance	IMP	17959650
double-strand break repair via homologous recombination	NAS	17765923
double-strand break repair via homologous recombination	IMP	17765923

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA replication

DNA-templated DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA replication

DNA-templated DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA replication

DNA-templated DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA replication

DNA-templated DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA replication

DNA-templated DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA replication

DNA-templated DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA replication

DNA-templated DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular process [inference]

cell cycle [inference]

meiotic cell cycle

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA replication

DNA-templated DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA replication

DNA-templated DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA replication

DNA-templated DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome

protein localization to site of double-strand break

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

telomere organization [inference]

telomere maintenance

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization

reproductive process [inference]

meiotic cell cycle

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome

protein localization to site of double-strand break

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome

protein localization to site of double-strand break

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	HDA	19135898
nucleus	IDA	17959650
nucleoplasm	TAS
nucleoplasm	IDA
DNA replication factor A complex	IDA	11927569 27723717 27723720

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

DNA replication factor A complex

cellular anatomical entity [inference]

nucleoplasm

nuclear body [inference]

PML body

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

site of DNA damage

site of double-strand break

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
damaged DNA binding	IDA	27723717 27723720 7700386
damaged DNA binding	IBA
single-stranded DNA binding	IDA	19010961 8990123
protein binding	IPI	10373438 10825162 11927569 12527904 1311258 15735006 15775963 15897895 15965237 17666013 17673209 19338310 20811460 2159011 24126761 24981860 25416956 26496610 27723717 27723720 28514442 28534480 29395061 32296183 33961781 34591612 7700386 7760808
zinc ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

single-stranded DNA binding

sequence-specific single stranded DNA binding [inference]

single-stranded telomeric DNA binding

G-rich strand telomeric DNA binding

sequence-specific DNA binding [inference]

telomeric DNA binding [inference]

single-stranded telomeric DNA binding

G-rich strand telomeric DNA binding

sequence-specific single stranded DNA binding [inference]

single-stranded telomeric DNA binding

G-rich strand telomeric DNA binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

chromatin-protein adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

replication

Functional Category

G: Carbohydrate transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
DNA recombination
DNA repair
damaged DNA binding
metal ion binding
single-stranded telomeric DNA binding
telomere maintenance via telomerase

Displaying **all 7** entries
InterPro
Nucleic acid-binding, OB-fold
OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
Replication factor A protein 1
Replication factor A, C-terminal, eukaryotes
Replication factor A, C-terminal
Replication factor-A protein 1, N-terminal
Replication protein A, OB domain

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6117	Xenbase:XB-GENE-945047
Mus musculus	68275	Xenbase:XB-GENE-945047	MOUSE03112
Rattus norvegicus	287524		RATNO01631
Danio rerio	327491		DANRE09307
Pan troglodytes	454414		PANTR13201
Bos taurus	504844		BOVIN12506
Macaca mulatta	721272		MACMU15003
Monodelphis domestica	100018386		MONDO15936
Equus caballus	100072427		HORSE02962
Ornithorhynchus anatinus	100075619		ORNAN08765

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OrthoDB (Group)

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Acknowledgements