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Submissions

ectonucleoside triphosphate diphosphohydrolase 8

Summary

Gene Symbol

Entpd8

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

613267

PubChem

613267

Alliance of Genome Resources

RGD:1561793

Annotation

Keyword

ATP-binding
Calcium
Cell membrane
Disulfide bond
Glycoprotein
Hydrolase
Magnesium
Metal-binding
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5DRK1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleoside monophosphate biosynthetic process	ISO
nucleoside monophosphate biosynthetic process	IEA
nucleoside diphosphate biosynthetic process	ISO
nucleoside diphosphate biosynthetic process	IEA
nucleoside diphosphate catabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

organic substance biosynthetic process [inference]

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

organic substance metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

organic substance biosynthetic process [inference]

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA
plasma membrane	IEA
membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
apyrase activity	IEA
GDP phosphatase activity	IBA
ATP binding	IEA
hydrolase activity	IEA
nucleoside diphosphate phosphatase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

apyrase activity

nucleoside diphosphate phosphatase activity

ribonucleoside triphosphate phosphatase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ectonucleoside triphosphate diphosphohydrolase

Functional Category

E: Amino acid transport and metabolism
F: Nucleotide transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
hydrolase activity
nucleotide binding

Displaying 1 entry
InterPro
Nucleoside phosphatase GDA1/CD39

Rhea

RHEA:36795

H₂O + a ribonucleoside 5'-triphosphate

H⁺ + phosphate + a ribonucleoside 5'-phosphate

Enzyme

3.6.1.5

PMID

RHEA:64912

H₂O + a 2'-deoxyribonucleoside 5'-triphosphate

H⁺ + phosphate + a 2'-deoxyribonucleoside 5'-phosphate

Enzyme

3.6.1.5

PMID

15576788

Ortholog

Displaying entries **1 - 10** of 61 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	72090	Xenbase:XB-GENE-996184	MOUSE34138
Homo sapiens	377841	Xenbase:XB-GENE-996184	HUMAN99469
Bos taurus	515532		BOVIN03549
Xenopus tropicalis	613267	Xenbase:XB-GENE-996184
Macaca mulatta	704424		MACMU13419
Equus caballus	100058558		HORSE24115
Oryctolagus cuniculus	100349881		RABIT17141
Callithrix jacchus	100386711		CALJA19650
Pongo abelii	100442938		PONAB35714
Ailuropoda melanoleuca	100468369		AILME05638

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Acknowledgements