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Guidelines

MIRAGE

ribosomal protein L18

Summary

Gene Symbol

RPL18

Organism

Homo sapiens (human)

External Links

NCBI Gene

6141

PubChem

6141

Alliance of Genome Resources

HGNC:10310

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Diamond-Blackfan anemia
Direct protein sequencing
Disease variant
Endoplasmic reticulum
Isopeptide bond
Phosphoprotein
Reference proteome
Ribosomal protein
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q07020	60S ribosomal protein L18

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytoplasmic translation	NAS	25901680
cytoplasmic translation	IC	23636399
cytoplasmic translation	IDA	25957688
translation	NAS	12962325

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

amide metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

protein metabolic process [inference]

cytoplasmic translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

cytoplasmic translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

cytoplasmic translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

cytoplasmic translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

primary metabolic process [inference]

protein metabolic process [inference]

cytoplasmic translation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

cytoplasmic translation

protein metabolic process [inference]

cytoplasmic translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

protein metabolic process [inference]

cytoplasmic translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

cytoplasmic translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

cytoplasmic translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
nucleus	HDA	21630459
nucleolus	IDA
cytoplasm	NAS	25901680
endoplasmic reticulum	IDA
rough endoplasmic reticulum	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex [inference]

ribosomal subunit [inference]

large ribosomal subunit [inference]

cytosolic large ribosomal subunit

cellular anatomical entity [inference]

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

endoplasmic reticulum

rough endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

ribosome [inference]

cytosolic ribosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

endoplasmic reticulum

rough endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

nucleolus

ribosome [inference]

cytosolic ribosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
RNA binding	IBA
structural constituent of ribosome	NAS	12962325
structural constituent of ribosome	IDA	23636399 32669547
structural constituent of ribosome	IBA
protein binding	IPI	30021884 32814053 33961781 35271311

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of ribosome

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ribosomal protein

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair

Displaying **all 2** entries
Gene Ontology
base-excision repair
catalytic activity

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111896	Diamond-Blackfan anemia 18	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 60 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6141	Xenbase:XB-GENE-1006303
Mus musculus	19899		MOUSE55117
Rattus norvegicus	81766		RATNO17045
Danio rerio	445038		DANRE09885
Pan troglodytes	456183		PANTR18836
Canis lupus familiaris	476422		CANLF00849
Bos taurus	509163		BOVIN11449
Macaca mulatta	704394		MACMU18007
Macaca mulatta	718136		MACMU18007
Felis catus	751614		FELCA33781

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025