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MIRAGE
steroid 5 alpha-reductase 1

Summary
Gene Symbol
  • SRD5A1
Organism
Bos taurus (domestic cattle)
NCBI Gene
614612
KEGG Gene ID
bta:614612
PubChem
614612
Annotation
Keyword
  • Lipid metabolism
  • Microsome
  • NADP
  • Oxidoreductase
  • Reference proteome
  • Sexual differentiation
  • Transmembrane helix
Proteins
Displaying 1 entry
UniProt Protein Name
A5PJS2
  • SR type 1
  • Steroid 5-alpha-reductase 1
Annotation information from UniProt.
Gene Ontology (GO)
Displaying 1 entry
GO Term Evidence Code PMID
membrane
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
3-oxo-5-alpha-steroid 4-dehydrogenase
Functional Category
  • E: Amino acid transport and metabolism
  • O: Posttranslational modification, protein turnover, chaperones
  • T: Signal transduction mechanisms
Displaying all 4 entries
Gene Ontology
3-oxo-5-alpha-steroid 4-dehydrogenase activity
lipid metabolic process
oxidoreductase activity, acting on the CH-CH group of donors
oxidoreductase activity
Displaying all 2 entries
InterPro
3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase
KEGG BRITE Database
Orthology
K12343
Name
3-oxo-5-alpha-steroid 4-dehydrogenase 1 [EC:1.3.1.22]
References
Rhea

RHEA:21952

5α-pregnane-3,20-dione + NADP+
H+ + progesterone + NADPH
Enzyme
PMID

RHEA:50820

17β-hydroxy-5α-androstan-3-one + NADP+
H+ + testosterone + NADPH
Enzyme
PMID

RHEA:54384

a 3-oxo-5α-steroid + NADP+
H+ + a 3-oxo-Δ4-steroid + NADPH
Enzyme
PMID
Ortholog
Displaying entries 1 - 10 of 72 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
6715 HUMAN78572
24950 RATNO16354
78925 MOUSE10430
403716 CANLF13452
695103 MACMU38810
743740 PANTR35025
767715 DANRE15790
100071450 HORSE20573
100125491 ORYLA02265
100176622 CIOIN04884
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025