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MIRAGE

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

Summary

Gene Symbol

SERPINA3

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 617667
PubChem: 617667

Annotation

Keyword

Cytoplasmic vesicle
Glycoprotein
Reference proteome
Secreted
Serine protease inhibitor
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
A2I7N1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
negative regulation of peptidase activity
negative regulation of endopeptidase activity	IEA	30032202

GO Hierarchy

biological process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular space	IEA	30032202
cytoplasmic vesicle
chromaffin granule

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

secretory vesicle [inference]

secretory granule [inference]

chromaffin granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

secretory vesicle [inference]

secretory granule [inference]

chromaffin granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

secretory vesicle [inference]

secretory granule [inference]

chromaffin granule

Displaying 1 entry
GO Term	Evidence Code	PMID
serine-type endopeptidase inhibitor activity	IEA	30032202

GO Hierarchy

molecular function

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serpin

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
serine-type endopeptidase inhibitor activity

Displaying **all 6** entries
InterPro
Serpin domain
Serpin family
Serpin superfamily, domain 1
Serpin superfamily, domain 2
Serpin superfamily
Serpin, conserved site

Ortholog

Displaying entries **1 - 10** of 62 in total

1

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Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	12		HUMAN21041
Mus musculus	16625		MOUSE09103
Mus musculus	20714		MOUSE09146
Mus musculus	20716		MOUSE09149
Mus musculus	20717		MOUSE09147
Rattus norvegicus	24794		RATNO36458
Rattus norvegicus	24795		RATNO36543
Mus musculus	74069		MOUSE09100
Mus musculus	238393		MOUSE09126
Rattus norvegicus	299276		RATNO36456

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Last updated: December 8, 2025