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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

acyl-CoA synthetase family member 2

Summary

Gene Symbol

Acsf2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

619561

PubChem

619561

Alliance of Genome Resources

RGD:1562656

Annotation

Keyword

ATP-binding
Acetylation
Fatty acid metabolism
Ligase
Mitochondrion
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q499N5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
lipid metabolic process	IEA
fatty acid metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

primary metabolic process [inference]

lipid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

lipid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
mitochondrion	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
catalytic activity	IEA
ATP binding	IEA
medium-chain fatty acid-CoA ligase activity	ISS
medium-chain fatty acid-CoA ligase activity	ISO
medium-chain fatty acid-CoA ligase activity	IBA

GO Hierarchy

molecular function

catalytic activity

ligase activity [inference]

ligase activity, forming carbon-sulfur bonds [inference]

CoA-ligase activity [inference]

medium-chain fatty acid-CoA ligase activity

acid-thiol ligase activity [inference]

fatty acid ligase activity [inference]

medium-chain fatty acid-CoA ligase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

fatty acid ligase activity [inference]

medium-chain fatty acid-CoA ligase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

4-coumarate--CoA ligase

Functional Category

K: Transcription
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
catalytic activity

Displaying **all 5** entries
InterPro
AMP-binding enzyme, C-terminal domain superfamily
AMP-binding enzyme, C-terminal domain
AMP-binding, conserved site
AMP-dependent synthetase/ligase domain
ANL, N-terminal domain

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026