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CAP-Gly domain containing linker protein 1

Summary

Gene Symbol

CLIP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6249

PubChem

6249

Alliance of Genome Resources

HGNC:10461

Annotation

Keyword

3D-structure
Alternative splicing
Cell projection
Coiled coil
Cytoplasmic vesicle
Cytoskeleton
Membrane
Microtubule
Phosphoprotein
Reference proteome
Repeat
Transport
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P30622	Cytoplasmic linker protein 1 Cytoplasmic linker protein 170 alpha-2 Reed-Sternberg intermediate filament-associated protein Restin
B3KXA5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitotic cell cycle	TAS	15928712
microtubule bundle formation	IMP	17889670
positive regulation of microtubule polymerization	IMP	15262990 17889670
positive regulation of microtubule polymerization	IBA
cytoplasmic microtubule organization	IBA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

cell cycle [inference]

mitotic cell cycle

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

supramolecular fiber organization [inference]

cytoplasmic microtubule organization

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

regulation of microtubule polymerization [inference]

positive regulation of microtubule polymerization

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

regulation of cytoskeleton organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

regulation of microtubule polymerization [inference]

positive regulation of microtubule polymerization

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

regulation of supramolecular fiber organization [inference]

regulation of microtubule polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
kinetochore	TAS	15928712
ruffle	IEA
nucleus	IBA
centrosome	IDA	21399614
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm [inference]

cell cortex

microtubule organizing center [inference]

centrosome

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

ruffle

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

pinosome [inference]

macropinosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

pinosome [inference]

macropinosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

pinosome [inference]

macropinosome

intracellular non-membrane-bounded organelle [inference]

kinetochore

cytoskeleton [inference]

microtubule cytoskeleton

supramolecular complex [inference]

kinetochore

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule end [inference]

microtubule plus-end

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11940666 16455083 17563362 17828275 17828277 19004523 20679239 21646404 24997520 26496610 26506308 27173435 32296183 35271311
microtubule binding	IDA	17889670
zinc ion binding	IDA	17828275
tubulin binding	IDA	17889670
identical protein binding	IPI	17828275 17828277

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding

microtubule binding

microtubule plus-end binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

CAP-GLY domain-containing linker protein 1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cytoplasmic microtubule organization
microtubule plus-end binding
positive regulation of microtubule polymerization

Displaying **all 3** entries
InterPro
CAP Gly-rich domain superfamily
CAP Gly-rich domain
CLIP1, zinc knuckle

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6249	Xenbase:XB-GENE-1012946
Drosophila melanogaster	7461	FB:FBgn0020503
Mus musculus	56430	Xenbase:XB-GENE-1012946	MOUSE44155
Rattus norvegicus	65201		RATNO04953
Drosophila melanogaster	269713	FB:FBgn0020503
Pan troglodytes	467147		PANTR07155
Canis lupus familiaris	477461		CANLF10270
Bos taurus	534624		BOVIN09426
Macaca mulatta	702137		MACMU03012
Monodelphis domestica	100016489		MONDO20317