GlyCosmos Portal

Submissions

glutathione peroxidase 4

Summary

Gene Symbol

Gpx4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

625249

PubChem

625249

Alliance of Genome Resources

MGI:104767

Annotation

Keyword

3D-structure
Alternative initiation
Alternative splicing
Cytoplasm
Developmental protein
Lipid metabolism
Mitochondrion
Nucleus
Peroxidase
Phosphoprotein
Reference proteome
Selenium
Selenocysteine
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q76LV0
O70325	Glutathione peroxidase 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	PMID
chromatin organization	IDA	11344099
apoptotic process	IMP	24599700
response to oxidative stress	IMP	25402683 29290465
spermatogenesis	IDA	11344099
spermatogenesis	IMP	25922076

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

olefinic compound metabolic process [inference]

arachidonic acid metabolic process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein polymerization

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

dendrite development

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization

protein-DNA complex organization [inference]

chromatin organization

cellular detoxification [inference]

cellular oxidant detoxification

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

multicellular organism growth

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure development [inference]

growth [inference]

developmental growth [inference]

multicellular organism growth

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to organic cyclic compound [inference]

response to estradiol

response to lipid [inference]

response to oxygen-containing compound [inference]

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of ferroptosis [inference]

negative regulation of ferroptosis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying entries **1 - 5** of 11 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
nucleus	IDA	11344099
nucleus	IBA
nuclear envelope	IDA	12566075
mitochondrion	IDA	12566075 15888450
mitochondrion	IBA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
glutathione peroxidase activity	ISO	11344099
glutathione peroxidase activity	IDA	11344099 19890015
glutathione peroxidase activity	IBA
selenium binding	ISO
selenium binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity [inference]

binding [inference]

protein binding [inference]

identical protein binding

selenium binding

antioxidant activity [inference]

peroxidase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

GLUTATHIONE PEROXIDASE

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
V: Defense mechanisms

Displaying **all 3** entries
Gene Ontology
cellular oxidant detoxification
oxidoreductase activity
response to oxidative stress

Displaying **all 3** entries
InterPro
Glutathione peroxidase conserved site
Glutathione peroxidase
Thioredoxin-like superfamily

Ortholog

Displaying entries **1 - 10** of 40 in total

1

2

3

4

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2879		HUMAN39330
Rattus norvegicus	29328		RATNO39426
Bos taurus	286809		BOVIN33375
Sus scrofa	399537		PIGXX18987
Xenopus tropicalis	625249	Xenbase:XB-GENE-990089
Macaca mulatta	705333		MACMU19199
Pan troglodytes	741876		PANTR16620
Danio rerio	852546	ZFIN:ZDB-GENE-030410-2
Danio rerio	853842	ZFIN:ZDB-GENE-030410-2
Ornithorhynchus anatinus	100088643		ORNAN29103