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glutathione peroxidase 4

Summary

Gene Symbol

Gpx4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

625249

PubChem

625249

Alliance of Genome Resources

MGI:104767

Annotation

Keyword

3D-structure
Alternative initiation
Alternative splicing
Cytoplasm
Developmental protein
Lipid metabolism
Mitochondrion
Nucleus
Peroxidase
Phosphoprotein
Reference proteome
Selenium
Selenocysteine
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q76LV0
O70325	Glutathione peroxidase 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 14** of 14 in total

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GO Term	Evidence Code	PMID
lipoxygenase pathway	ISO ISS
dendrite development	IMP	24599700
response to oxidative stress	IMP	25402683 29290465
response to estradiol	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

olefinic compound metabolic process [inference]

arachidonic acid metabolic process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein polymerization

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

dendrite development

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization

protein-DNA complex organization [inference]

chromatin organization

cellular detoxification [inference]

cellular oxidant detoxification

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

multicellular organism growth

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure development [inference]

growth [inference]

developmental growth [inference]

multicellular organism growth

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to organic cyclic compound [inference]

response to estradiol

response to lipid [inference]

response to oxygen-containing compound [inference]

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of ferroptosis [inference]

negative regulation of ferroptosis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein-containing complex	IEA ISO
mitochondrial inner membrane	HDA	12865426
mitochondrion	HDA IBA IDA	12566075 14651853 15888450 18614015
nuclear envelope	IDA	12566075
nucleus	IBA IDA	11344099

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
selenium binding	IEA ISO
phospholipid-hydroperoxide glutathione peroxidase activity	IBA IDA ISO	25402683 29290465
identical protein binding	IEA ISO
glutathione peroxidase activity	IBA IDA ISO	11344099 19890015

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity [inference]

binding [inference]

protein binding [inference]

identical protein binding

selenium binding

antioxidant activity [inference]

peroxidase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

phospholipid hydroperoxide glutathione peroxidase

Functional Category

J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 6** entries
Gene Ontology
cellular oxidant detoxification
cellular response to chemical stimulus
cellular response to oxidative stress
oxidoreductase activity
phospholipid-hydroperoxide glutathione peroxidase activity
response to oxidative stress

Displaying **all 2** entries
InterPro
Glutathione peroxidase
Thioredoxin-like superfamily

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050861	colorectal adenocarcinoma	Alliance of Genome Resources
DOID:0112298	spondylometaphyseal dysplasia Sedaghatian type	Alliance of Genome Resources
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:1184	nephrotic syndrome	Alliance of Genome Resources
DOID:219	colon cancer	Alliance of Genome Resources
DOID:3021	acute kidney failure	Alliance of Genome Resources
DOID:3717	gastric adenocarcinoma	Alliance of Genome Resources
DOID:9256	colorectal cancer	Alliance of Genome Resources

Ortholog

Displaying entries **61 - 70** of 82 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mastomys coucha	116075700	35658_0:003d78
Rattus rattus	116905409	10117_0:0008a2
Rhinolophus ferrumequinum	117037754			RHIFE15348
Arvicanthis niloticus	117696848	61156_0:0049e2
Onychomys torridus	118571411	38674_0:0045f6
Balaenoptera musculus	118893604			BALMU07933
Arvicola amphibius	119820907	1047088_0:0003f8
Microtus oregoni	121459510	111838_0:002e75
Dipodomys spectabilis	122122854	105255_0:003561
Panthera leo	122213671			PANLE22460

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Last updated: December 9, 2024